{"id":"W2094563784","doi":"10.1016/j.bmc.2007.11.003","title":"Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Acetylene; Structural isomer; Cyclooxygenase; Stereochemistry; Inhibitory postsynaptic potential; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008869236,0.0004943432,0.0008177306,0.00005954082,0.0001616042,0.00001553181,0.0003871824,0.0005986527,0.002253547],"category_scores_gemma":[0.001535813,0.0003583617,0.0001821928,0.0002826349,0.000714581,0.0001084346,0.0001954721,0.0004594456,0.000006736592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001465936,"about_ca_system_score_gemma":0.0001678619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001025368,"about_ca_topic_score_gemma":0.00001521584,"domain_scores_codex":[0.9973024,0.00003411819,0.0007109947,0.0007324961,0.000586168,0.0006337913],"domain_scores_gemma":[0.9969739,0.001523408,0.0004496699,0.0005762451,0.00009054686,0.0003862851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008137483,0.0003557413,0.001544183,0.0007451291,0.0001231163,0.00008995125,0.0001346795,1.441985e-7,0.9796338,0.000005853902,0.0002171036,0.01633656],"study_design_scores_gemma":[0.0006587179,0.00007188976,0.001725902,0.0003416656,0.0001445664,0.0001769683,0.002974577,0.00001181298,0.9903628,0.00002383581,0.003065212,0.0004420054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929717,0.001378043,0.00005370974,0.0002571923,0.000100171,0.00007926252,0.00007717911,0.000139775,0.004942963],"genre_scores_gemma":[0.996718,0.0006145086,0.0003675134,0.00008976083,0.001008641,0.00001353377,0.00001842747,0.00005198651,0.001117556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01589456,"threshold_uncertainty_score":0.9998868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01984767476630455,"score_gpt":0.2466012489343532,"score_spread":0.2267535741680486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}