{"id":"W2094586902","doi":"10.1074/jbc.m411487200","title":"TCF-4 Mediates Cell Type-specific Regulation of Proglucagon Gene Expression by β-Catenin and Glycogen Synthase Kinase-3β","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":411,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Proglucagon; Biology; Glycogen synthase; GSK-3; Gene expression; Wnt signaling pathway; Molecular biology; GSK3B; Gene knockdown; Kinase; Endocrinology; Internal medicine; Signal transduction; Cell biology; Gene; Insulin; Biochemistry; Glucagon-like peptide-1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693376,0.0001077289,0.0003042003,0.00002362513,0.00002656929,0.000006661706,0.0000535992,0.0001776543,0.000252441],"category_scores_gemma":[0.0002375014,0.00006658067,0.00007257963,0.00008343784,0.0001051368,0.00003642513,0.00002083639,0.0001543792,0.000003157145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004089844,"about_ca_system_score_gemma":0.0000465393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.244804e-7,"about_ca_topic_score_gemma":6.648707e-9,"domain_scores_codex":[0.9992002,0.00001774691,0.000370465,0.0001275874,0.0001660855,0.0001178978],"domain_scores_gemma":[0.9992194,0.00007700743,0.0002960038,0.0000925436,0.0001484749,0.0001666373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005046462,0.0002365065,0.003518757,0.00007064301,0.00001543559,0.00001437686,0.00002352007,0.00000498936,0.9943669,0.000001269359,0.000846312,0.0003966708],"study_design_scores_gemma":[0.001593284,0.000434712,0.003003939,0.000136823,0.00003592615,0.00008358498,0.0000795092,0.000004591843,0.9934945,0.0001673626,0.0008962345,0.0000695047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936641,0.005403453,0.0000643589,0.0001997158,0.00005345136,0.00006427156,0.000008745617,0.00001082955,0.0005310574],"genre_scores_gemma":[0.9966353,0.0007820969,0.002185074,0.00004003531,0.0001830457,0.000001529122,0.00003801291,0.000006042782,0.0001289257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004621357,"threshold_uncertainty_score":0.2764052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02118491295124086,"score_gpt":0.2378308381213265,"score_spread":0.2166459251700856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}