{"id":"W2094589586","doi":"10.1016/j.cell.2007.02.047","title":"Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network","year":2007,"lang":"en","type":"article","venue":"Cell","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":707,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Institute of Mental Health; Howard Hughes Medical Institute","keywords":"Biology; Circadian clock; Robustness (evolution); Circadian rhythm; Cell biology; Biological clock; Intracellular; Genetics; Computational biology; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006104564,0.0001294791,0.0001230419,0.0001013232,0.0002044625,0.00007469111,0.0003009864,0.00008921175,0.00003886457],"category_scores_gemma":[0.00007932086,0.0001130727,0.00006331437,0.0005201382,0.000136712,0.00008915002,0.00002897976,0.0003401302,0.0001367889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005530617,"about_ca_system_score_gemma":0.0000591351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001340293,"about_ca_topic_score_gemma":0.00004545875,"domain_scores_codex":[0.9987103,0.00005119183,0.000254031,0.0003022472,0.0001769754,0.0005052299],"domain_scores_gemma":[0.9991255,0.000389609,0.00006741612,0.0002866069,0.00001893303,0.0001119024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006889911,0.0004239101,0.01612593,0.0001117675,0.000008839745,0.002268106,0.01570419,0.6501894,0.2628286,0.04537283,0.002902217,0.003995368],"study_design_scores_gemma":[0.003048772,0.0001249263,0.02847345,0.0002587442,0.00005452982,0.0001753354,0.008127847,0.1529922,0.7061716,0.000580835,0.0986411,0.001350706],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967712,0.0003176661,0.004018925,0.0001858898,0.0005684231,0.0002888369,0.00000278433,0.00004459151,0.02686083],"genre_scores_gemma":[0.9977712,0.00003930255,0.00007362694,0.001322842,0.000244197,0.000009522015,0.000006973808,0.0000207544,0.0005115647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4971972,"threshold_uncertainty_score":0.4610969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02780140207630814,"score_gpt":0.2509198682298862,"score_spread":0.2231184661535781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}