{"id":"W2094611598","doi":"10.1182/blood-2014-03-559963","title":"The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"GlaxoSmithKline","keywords":"Multiple myeloma; Pharmacokinetics; Medicine; Lenalidomide; Safety profile; Protein kinase B; Cancer research; Pharmacology; Oncology; Internal medicine; Adverse effect; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008987093,0.0001860667,0.0003437204,0.00007063116,0.0001936665,0.00004830946,0.0001363735,0.0001171924,0.00002808461],"category_scores_gemma":[0.001431491,0.0001220455,0.0000933994,0.0001458786,0.0002103647,0.00007897394,0.0001702201,0.0004385284,0.0000338157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003447926,"about_ca_system_score_gemma":0.00009041684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002492066,"about_ca_topic_score_gemma":0.0009273397,"domain_scores_codex":[0.9981966,0.0001875466,0.0003503457,0.0003901655,0.0003695465,0.0005057713],"domain_scores_gemma":[0.9980114,0.001088619,0.00007078149,0.0004027007,0.00007501849,0.000351458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001943861,0.003515128,0.8536294,0.00006196655,0.0002799327,0.00006846604,0.00005356821,0.000001654207,0.04057223,0.00004657773,0.0003687913,0.09945849],"study_design_scores_gemma":[0.03196459,0.0007638189,0.9072706,0.0000759196,0.0001300423,0.00003734619,0.00002943627,0.005722786,0.04192781,0.00003908149,0.01187107,0.0001675086],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957197,0.0002952457,0.00009798577,0.001392375,0.0001355168,0.0007069454,0.0000264183,0.00004098433,0.001584875],"genre_scores_gemma":[0.9977163,0.0003830573,0.0006523323,0.0001208137,0.0003455197,0.00003669054,0.00001262384,0.00002699304,0.0007056489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09929099,"threshold_uncertainty_score":0.4976873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04141649061552355,"score_gpt":0.3380243069075684,"score_spread":0.2966078162920448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}