{"id":"W2094611598","doi":"10.1182/blood-2014-03-559963","title":"The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"GlaxoSmithKline","keywords":"Multiple myeloma; Pharmacokinetics; Medicine; Lenalidomide; Safety profile; Protein kinase B; Cancer research; Pharmacology; Oncology; Internal medicine; Adverse effect; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004671439,0.0003794569,0.0008524071,0.0002280477,0.0002172812,0.0003714426,0.000272307,0.0002442342,0.0005632825],"category_scores_gemma":[0.0002978829,0.000178447,0.0003043761,0.0003746742,0.0002844943,0.0003778363,0.000160037,0.0008237691,0.0001769537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004717478,"about_ca_system_score_gemma":0.0003738206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008917659,"about_ca_topic_score_gemma":0.003045161,"domain_scores_codex":[0.999845,0.00003047261,0.00001231365,0.00002718154,0.00005646985,0.00002851362],"domain_scores_gemma":[0.9998516,0.00002865491,0.00005497114,0.00001274232,0.00001308479,0.00003892302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01892933,0.003693506,0.01461119,0.0003910148,0.0004160896,0.000627913,0.0001627649,0.004585071,0.7042081,0.0002970971,0.001742273,0.2503357],"study_design_scores_gemma":[0.02154069,0.2755596,0.2238049,0.00009398453,0.001115535,0.009392451,0.0001274475,0.01247847,0.4370129,0.0005657408,0.01816615,0.0001419987],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99256,0.005641832,0.0007401111,0.0001186212,0.00001348873,0.00006458857,0.000179668,0.00007304014,0.0006085224],"genre_scores_gemma":[0.9947168,0.002473131,0.001484662,0.00008834301,0.00003466567,0.00004015387,0.0005913141,0.00001390682,0.0005571386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008917659,"threshold_uncertainty_score":0.003422737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04141649061552355,"score_gpt":0.3380243069075684,"score_spread":0.2966078162920448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}