{"id":"W2094617720","doi":"10.1016/j.matbio.2005.11.003","title":"Generation of a transgenic mouse in which Cre recombinase is expressed under control of the type II collagen promoter and doxycycline administration","year":2005,"lang":"en","type":"article","venue":"Matrix Biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"","keywords":"Cre recombinase; Transgene; Biology; Conditional gene knockout; Genetically modified mouse; Doxycycline; Gene knockout; Recombinase; Molecular biology; Gene expression; Gene; Gene targeting; Reporter gene; Cre-Lox recombination; Embryonic stem cell; Cell biology; Phenotype; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007425383,0.0009132457,0.0006831823,0.001645532,0.0005406013,0.0005607143,0.00100009,0.001284623,0.005554956],"category_scores_gemma":[0.0003235657,0.000795214,0.0006718033,0.0004597155,0.0005459738,0.0006461848,0.0004974055,0.001832384,0.003385593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003573064,"about_ca_system_score_gemma":0.000485998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007960663,"about_ca_topic_score_gemma":0.001238259,"domain_scores_codex":[0.9996264,0.00003606801,0.00005491904,0.00008734716,0.0001255528,0.00006968752],"domain_scores_gemma":[0.9993746,0.00008878318,0.0001364181,0.0001035191,0.00008614012,0.0002105796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001076925,0.00008305432,0.00009119367,0.00002671546,0.000007291128,0.0001226092,0.00002621168,0.00002947539,0.9972872,0.000673301,0.0001910924,0.00135428],"study_design_scores_gemma":[0.0001658163,0.0003498437,0.001677406,0.00002565923,0.0000629856,0.001077524,0.00002974922,0.0008154996,0.9747311,0.0002441893,0.02079786,0.00002235593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8270994,0.002380213,0.1374318,0.001559762,0.001053583,0.002055925,0.01047508,0.002882279,0.01506191],"genre_scores_gemma":[0.7636738,0.003986769,0.121848,0.0006693895,0.0002110109,0.002099319,0.01423122,0.001389631,0.09189096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005554956,"threshold_uncertainty_score":0.01858312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02845044991376712,"score_gpt":0.3244314793153949,"score_spread":0.2959810294016278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}