{"id":"W2094644882","doi":"10.1039/c3cs60264h","title":"Functional DNA switches: rational design and electrochemical signaling","year":2013,"lang":"en","type":"review","venue":"Chemical Society Reviews","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"DNA; Nanotechnology; Deoxyribozyme; Aptamer; DNA nanotechnology; Rational design; Electrochemistry; Chemistry; Molecular switch; Electrode; Materials science; Molecule; Biology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001183121,0.001510968,0.001298981,0.001431084,0.0002853588,0.001071785,0.001482624,0.001696368,0.001301491],"category_scores_gemma":[0.0005986508,0.0008272933,0.0004862712,0.001659596,0.001017109,0.001982667,0.000912412,0.002378674,0.002541308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001432316,"about_ca_system_score_gemma":0.000685073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00072433,"about_ca_topic_score_gemma":0.0008523591,"domain_scores_codex":[0.9996093,0.00005491266,0.00003292264,0.00008597411,0.0001591017,0.00005782277],"domain_scores_gemma":[0.9998791,0.00004276435,0.00002045965,0.000007662825,0.00003921038,0.0000107096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009922863,0.0002303729,0.0001522244,0.0140085,0.0001122248,0.0006070797,0.0002497347,0.004854866,0.1357677,0.1041411,0.01957179,0.7202052],"study_design_scores_gemma":[0.000042322,0.0002127854,0.0001497619,0.0008714263,0.00005322988,0.000781463,0.00004899354,0.001460818,0.06777279,0.01035552,0.918179,0.00007198639],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00281127,0.9716603,0.01686198,0.0008094975,0.0006473859,0.00009383442,0.00008096658,0.0001214689,0.00691331],"genre_scores_gemma":[0.01300693,0.967963,0.01325142,0.0006151899,0.0001946904,0.000175108,0.0001345325,0.00002478766,0.004634271],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001696368,"threshold_uncertainty_score":0.01039219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05128287555156544,"score_gpt":0.3139459537206072,"score_spread":0.2626630781690418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}