{"id":"W2094651511","doi":"10.1016/j.exphem.2005.06.024","title":"KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity","year":2005,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; Canadian Blood Services; Ontario Institute for Cancer Research","funders":"Medical Research Council; University of Toronto; National Health and Medical Research Council; University Health Network","keywords":"Perforin; Cytotoxicity; Granzyme; Granzyme B; Cytotoxic T cell; Natural killer cell; NKG2D; Lymphokine-activated killer cell; Cytolysis; Cell culture; Biology; Molecular biology; Cell biology; K562 cells; Cancer research; Chemistry; Interleukin 21; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000352889,0.0005508609,0.0004798333,0.0004472722,0.0003084889,0.0006319643,0.0007982,0.0005420457,0.001606782],"category_scores_gemma":[0.0002489767,0.0001526069,0.0003298054,0.0002750538,0.0006798481,0.0006843774,0.0004510238,0.001912919,0.0005203612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007575019,"about_ca_system_score_gemma":0.0002294481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006050449,"about_ca_topic_score_gemma":0.0003963484,"domain_scores_codex":[0.9997354,0.00005885902,0.00001671535,0.00005623366,0.00005852246,0.00007432554],"domain_scores_gemma":[0.9997683,0.00007014519,0.0000596153,0.00004395241,0.00001158586,0.00004645759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005526445,0.0001229071,0.0001764472,0.00005372609,0.000008120552,0.0001219682,0.00003501452,0.0003908138,0.9925007,0.003597885,0.0001922173,0.002247448],"study_design_scores_gemma":[0.0002625491,0.001553801,0.002361359,0.0000153583,0.00004750879,0.001084839,0.00006652217,0.00542141,0.977532,0.002806255,0.00882037,0.00002799132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793818,0.003026207,0.01154391,0.0004998799,0.000157533,0.0001237006,0.0007906096,0.000194526,0.004281889],"genre_scores_gemma":[0.9885689,0.001169477,0.0048598,0.0001223743,0.00005273246,0.0000833216,0.000661307,0.00005892731,0.00442327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001606782,"threshold_uncertainty_score":0.005496085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586394707672532,"score_gpt":0.2835278542068425,"score_spread":0.2676639071301172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}