{"id":"W2094661145","doi":"10.1128/jvi.02904-13","title":"The Connection Domain Mutation N348I in HIV-1 Reverse Transcriptase Enhances Resistance to Etravirine and Rilpivirine but Restricts the Emergence of the E138K Resistance Mutation by Diminishing Viral Replication Capacity","year":2013,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institutes of Health; National Institute for Health and Care Research","keywords":"Rilpivirine; Resistance mutation; Etravirine; Virology; Reverse transcriptase; Biology; Mutation; Lamivudine; Nucleoside Reverse Transcriptase Inhibitor; Nevirapine; Reverse-transcriptase inhibitor; Context (archaeology); Virus; Genetics; Viral load; Gene; RNA; Hepatitis B virus; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009520742,0.0003021928,0.0001629014,0.0001126811,0.0001906564,0.0001665918,0.0002744099,0.0003839528,0.001744324],"category_scores_gemma":[0.000270149,0.0001000326,0.0001949267,0.0001131126,0.0002767101,0.0001522162,0.0002208895,0.0004351149,0.0002563039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002527406,"about_ca_system_score_gemma":0.0001740512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005613706,"about_ca_topic_score_gemma":0.0007731856,"domain_scores_codex":[0.9998598,0.00002948929,0.00001190303,0.00003142689,0.00004598299,0.00002134097],"domain_scores_gemma":[0.9999046,0.00002126251,0.00003620647,0.000008048703,0.000008023351,0.00002179904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004113057,0.000155544,0.003757087,0.00003955339,0.00002397543,0.0007308497,0.00002783173,0.0004784467,0.9853008,0.0005900159,0.000178209,0.008306375],"study_design_scores_gemma":[0.0003154995,0.002498292,0.03927246,0.00003221789,0.0001170998,0.01041392,0.00009678164,0.007284146,0.9269083,0.0008982406,0.01211528,0.00004780852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978847,0.0002256017,0.0005655973,0.00006449946,0.00001512907,0.00001622847,0.00007650163,0.00002007344,0.001131614],"genre_scores_gemma":[0.9987967,0.00009201046,0.0004983152,0.00003266271,0.000004524868,0.000007005012,0.00008214967,0.000006964997,0.0004796585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001744324,"threshold_uncertainty_score":0.005835354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014737479234531,"score_gpt":0.2456297398879978,"score_spread":0.2354823650956525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}