{"id":"W2094665308","doi":"10.1016/j.chembiol.2014.07.014","title":"Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3","year":2014,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; Versus Arthritis; Wellcome Trust","keywords":"ADAMTS; Sulfation; Thrombospondin; Extracellular matrix; Glycosaminoglycan; Matrix metalloproteinase; Metalloproteinase; Biochemistry; Cell biology; Chondroitin sulfate; Chemistry; Heparan sulfate; Glycan; Thrombospondins; Tissue inhibitor of metalloproteinase; Disintegrin; Biology; Glycoprotein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001360648,0.0002079194,0.0001534049,0.0001532827,0.0001527353,0.0004862343,0.0001391436,0.0001561117,0.0009165398],"category_scores_gemma":[0.0001693975,0.000112161,0.0001919429,0.00009619354,0.0002143099,0.0002044227,0.0001814882,0.0003245367,0.0003614107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004294876,"about_ca_system_score_gemma":0.0002632888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009956558,"about_ca_topic_score_gemma":0.0009061654,"domain_scores_codex":[0.9998502,0.00002690929,0.00001184912,0.00002036237,0.00003568469,0.00005508311],"domain_scores_gemma":[0.9998915,0.00001288011,0.00003225367,0.000009531776,0.00002398847,0.0000297643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000138865,0.0000161687,0.0003296571,0.00001008628,0.000002315496,0.00003629745,0.00001048914,0.00005396985,0.9980826,0.000137156,0.0000496684,0.001132768],"study_design_scores_gemma":[0.00002146424,0.0001752403,0.01641489,0.000005029241,0.00001441709,0.0001730964,0.00007313236,0.002136831,0.9777443,0.0001589374,0.003076617,0.000005960319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938043,0.002202644,0.001975392,0.000130293,0.0000392755,0.00001296253,0.0001232249,0.00005056037,0.001661282],"genre_scores_gemma":[0.9964181,0.0007878215,0.0007054061,0.00004088016,0.00001338638,0.000009212736,0.00007587667,0.0000105171,0.001938794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009956558,"threshold_uncertainty_score":0.003116131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004904122850206568,"score_gpt":0.1999131352962743,"score_spread":0.1950090124460678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}