{"id":"W2094670989","doi":"10.1124/dmd.105.008227","title":"P-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrile","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Digoxin; Glycoprotein; Chemistry; P-glycoprotein; Pregnenolone; Internal medicine; Endocrinology; Absorption (acoustics); Biophysics; Chromatography; Biochemistry; Biology; Materials science; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004589492,0.0004130073,0.0004071918,0.000287602,0.0003446599,0.0004233844,0.0004929914,0.0004696814,0.001338014],"category_scores_gemma":[0.000463807,0.0005109702,0.0004514145,0.0002956869,0.0008623296,0.001048246,0.0002425915,0.001175405,0.0003420018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005516778,"about_ca_system_score_gemma":0.0007282059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003696457,"about_ca_topic_score_gemma":0.003169498,"domain_scores_codex":[0.999819,0.00003676073,0.000008226509,0.00003337909,0.00002598245,0.00007670974],"domain_scores_gemma":[0.9996555,0.0001481088,0.00005408785,0.00005930166,0.00003367724,0.00004932576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002072823,0.00004002077,0.0002742548,0.00005416861,0.00001398965,0.0002735719,0.0001382502,0.0001004916,0.9950002,0.0005201208,0.00003311586,0.001479078],"study_design_scores_gemma":[0.00005852796,0.0006402761,0.00353934,0.000004070118,0.00004751034,0.0001963881,0.0001059235,0.0009700329,0.9936346,0.0001380374,0.0006554139,0.000009859615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937468,0.001443272,0.002887667,0.0001594826,0.00003056324,0.00002683191,0.0001533328,0.00005755539,0.001494491],"genre_scores_gemma":[0.9933562,0.000840823,0.002496936,0.00006039886,0.00002911665,0.00002027435,0.0002885239,0.00004566116,0.002862156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003696457,"threshold_uncertainty_score":0.007349849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01580353113050918,"score_gpt":0.2509502275886694,"score_spread":0.2351466964581602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}