{"id":"W2094705328","doi":"10.1161/circulationaha.112.000855","title":"H <sub>2</sub> S Protects Against Pressure Overload–Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase","year":2013,"lang":"en","type":"article","venue":"Circulation","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":350,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Heart failure; Medicine; Nitric oxide; Pressure overload; Downregulation and upregulation; Nitric oxide synthase; Cardiac function curve; Internal medicine; Knockout mouse; Constriction; Endothelial dysfunction; Endocrinology; Nitric Oxide Synthase Type III; Cardiology; Enos; Chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001772531,0.0005381397,0.0003981609,0.000195339,0.0001308883,0.0002510295,0.0002049055,0.0002821037,0.001359116],"category_scores_gemma":[0.00008517024,0.0001359558,0.000257732,0.00009560973,0.0004936083,0.0002387333,0.000170568,0.0005956165,0.0002378647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001906464,"about_ca_system_score_gemma":0.0002135725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003170684,"about_ca_topic_score_gemma":0.0005397492,"domain_scores_codex":[0.9999241,0.00001336078,0.000009900908,0.00001372933,0.00001448984,0.0000243979],"domain_scores_gemma":[0.9998633,0.000008621656,0.00005424752,0.00001256338,0.00001127762,0.00004999303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002540606,0.0002041426,0.0007399892,0.0001063814,0.00002745547,0.0001060024,0.00001794615,0.00006439677,0.9928104,0.00006356039,0.0001569474,0.003162315],"study_design_scores_gemma":[0.0004572723,0.005103348,0.03390704,0.00003358363,0.0001225553,0.0005385975,0.0001106235,0.0009199185,0.9560519,0.000137319,0.002602408,0.00001547057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960855,0.001426957,0.001203725,0.0001690771,0.00006325354,0.00002543866,0.0002353251,0.0001397733,0.0006509815],"genre_scores_gemma":[0.9956774,0.0009143891,0.001167446,0.0001444307,0.00005675963,0.00006360816,0.0003861249,0.00002346496,0.001566382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001359116,"threshold_uncertainty_score":0.004546642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009038204858086834,"score_gpt":0.2171454388524361,"score_spread":0.2081072339943493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}