{"id":"W2094713052","doi":"10.2147/ijn.s77734","title":"Peptide gH625 enters into neuron and astrocyte cell lines and crosses the blood–brain barrier in rats","year":2015,"lang":"en","type":"article","venue":"International Journal of Nanomedicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Blood–brain barrier; Astrocyte; In vivo; Nanocarriers; P-glycoprotein; Neurite; Pharmacology; In vitro; Central nervous system; Drug delivery; Cell biology; Biology; Chemistry; Neuroscience; Drug; Biochemistry; Multiple drug resistance; Antibiotics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001443424,0.0003822004,0.0002715424,0.0002038701,0.0001388367,0.0001835683,0.0001365687,0.0002922718,0.001234927],"category_scores_gemma":[0.0000892349,0.000111294,0.0002065956,0.0001022234,0.0002628959,0.0002735124,0.0001295944,0.0004939486,0.0003658946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000229168,"about_ca_system_score_gemma":0.0002558117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000911131,"about_ca_topic_score_gemma":0.0013329,"domain_scores_codex":[0.9998981,0.0000150377,0.000009221655,0.00002438094,0.00002563008,0.00002763097],"domain_scores_gemma":[0.9999374,0.00001092161,0.00001599219,0.000007965959,0.000008944161,0.00001877648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001381381,0.00003084902,0.0000585745,0.00003517255,0.000003219223,0.00004180841,0.00001817794,0.0000317345,0.9981788,0.00007012268,0.00002152818,0.00137183],"study_design_scores_gemma":[0.00001278014,0.0008137277,0.0008112947,0.000004301556,0.000008292525,0.0001120712,0.00002303877,0.0003025253,0.9966633,0.00004400926,0.001201403,0.000003179831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922829,0.00103571,0.004354815,0.00007918776,0.00004394544,0.00004253866,0.0002343852,0.00006264315,0.001863848],"genre_scores_gemma":[0.9847354,0.001175843,0.007512501,0.00006192867,0.00001459407,0.00006357261,0.0004775391,0.00002619736,0.005932549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001234927,"threshold_uncertainty_score":0.004131198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660408537017476,"score_gpt":0.2857191402285564,"score_spread":0.2691150548583816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}