{"id":"W2094713052","doi":"10.2147/ijn.s77734","title":"Peptide gH625 enters into neuron and astrocyte cell lines and crosses the blood–brain barrier in rats","year":2015,"lang":"en","type":"article","venue":"International Journal of Nanomedicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Blood–brain barrier; Astrocyte; In vivo; Nanocarriers; P-glycoprotein; Neurite; Pharmacology; In vitro; Central nervous system; Drug delivery; Cell biology; Biology; Chemistry; Neuroscience; Drug; Biochemistry; Multiple drug resistance; Antibiotics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003876847,0.0001287965,0.0001572156,0.0001276886,0.00002949286,0.00005131108,0.0002780085,0.00005992747,0.00001574744],"category_scores_gemma":[0.0003175082,0.00008665941,0.00004858433,0.00004578644,0.0001706352,0.00002003921,0.0001316399,0.000155655,0.000002624422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001589609,"about_ca_system_score_gemma":0.00009833318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005148188,"about_ca_topic_score_gemma":0.0001734975,"domain_scores_codex":[0.999032,0.00005420795,0.0003575211,0.0001615535,0.0002686451,0.0001260541],"domain_scores_gemma":[0.9991684,0.00004013104,0.0002020644,0.0001141747,0.0003478293,0.0001273966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006556124,0.0000886886,0.06144689,0.00001293275,0.0001364192,0.00006904206,0.0009998867,0.00004957861,0.9170086,0.000007156294,0.01679104,0.002734181],"study_design_scores_gemma":[0.01034252,0.003813751,0.06413173,0.000516608,0.0001554772,0.002558529,0.00207068,0.00009102113,0.1985199,0.0004404346,0.7168073,0.000552072],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916764,0.002914045,0.0002623264,0.004223137,0.0007027396,0.00005326598,0.00000707319,0.000001781679,0.0001592696],"genre_scores_gemma":[0.9939726,0.001130486,0.0003578689,0.001565986,0.0008028146,0.00000194896,0.0000177622,0.00001024205,0.002140268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7184887,"threshold_uncertainty_score":0.3533868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660408537017476,"score_gpt":0.2857191402285564,"score_spread":0.2691150548583816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}