{"id":"W2094727741","doi":"10.1074/jbc.m407186200","title":"Characterization of the Distinct Collagen Binding, Helicase and Cleavage Mechanisms of Matrix Metalloproteinase 2 and 14 (Gelatinase A and MT1-MMP)","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canadian Institutes of Health Research","funders":"","keywords":"Matrix metalloproteinase; Hemopexin; Gelatinase; Gelatinase A; Fibronectin; Chemistry; Type I collagen; Extracellular matrix; Cleavage (geology); Collagen receptor; Collagen, type I, alpha 1; Type IV collagen; Collagenase; Recombinant DNA; Biochemistry; Integrin; Laminin; Biology; Cell; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586097,0.0002091607,0.0001455895,0.0002122651,0.00009457736,0.0002271878,0.000136179,0.000239111,0.0005700174],"category_scores_gemma":[0.0002204112,0.00009079668,0.0002311481,0.0001185205,0.0001470538,0.0001690101,0.0001014387,0.000296948,0.0002577962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001751704,"about_ca_system_score_gemma":0.0001610773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006669168,"about_ca_topic_score_gemma":0.0005056397,"domain_scores_codex":[0.9999089,0.000009121302,0.000006668566,0.00002091085,0.00002759956,0.0000267561],"domain_scores_gemma":[0.9998467,0.00003611554,0.00003927085,0.00001407917,0.00002862664,0.00003521069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002385999,0.000007946674,0.000239825,0.00001022978,0.000001295168,0.00002220282,0.000006098938,0.00001228534,0.9993184,0.00002544938,0.000005799337,0.0003266516],"study_design_scores_gemma":[0.00001072923,0.0002217974,0.01995977,0.000004310554,0.00001597896,0.001127573,0.00003060195,0.0009975695,0.9758188,0.00006067797,0.001746441,0.000005834038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943591,0.00135689,0.003225735,0.0000517778,0.00001019707,0.00002759253,0.0003453197,0.00001555056,0.0006078415],"genre_scores_gemma":[0.9924285,0.0006499256,0.004232772,0.00005418975,0.00001042763,0.00002975244,0.001188255,0.000007220527,0.001398921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006669168,"threshold_uncertainty_score":0.001906931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009307174000227441,"score_gpt":0.2262444910825721,"score_spread":0.2169373170823447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}