{"id":"W2094727741","doi":"10.1074/jbc.m407186200","title":"Characterization of the Distinct Collagen Binding, Helicase and Cleavage Mechanisms of Matrix Metalloproteinase 2 and 14 (Gelatinase A and MT1-MMP)","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canadian Institutes of Health Research","funders":"","keywords":"Matrix metalloproteinase; Hemopexin; Gelatinase; Gelatinase A; Fibronectin; Chemistry; Type I collagen; Extracellular matrix; Cleavage (geology); Collagen receptor; Collagen, type I, alpha 1; Type IV collagen; Collagenase; Recombinant DNA; Biochemistry; Integrin; Laminin; Biology; Cell; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002801767,0.0001345908,0.0002484542,0.00001664211,0.00005713309,0.00001217691,0.0001071781,0.0002003397,0.000009794486],"category_scores_gemma":[0.0002311828,0.00008390056,0.00008247922,0.00006503789,0.0001660466,0.000007853651,0.0001588779,0.00009517562,1.042627e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000880832,"about_ca_system_score_gemma":0.00004401394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002669146,"about_ca_topic_score_gemma":4.932504e-7,"domain_scores_codex":[0.9991968,0.00004337631,0.0003606939,0.0001692614,0.0001146727,0.0001151817],"domain_scores_gemma":[0.9991937,0.00001205593,0.0004804305,0.0001309386,0.00008488036,0.0000980508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001628306,0.00006406911,0.0002942053,0.00007968961,0.0000353304,0.00001071906,0.00001581679,3.564651e-7,0.9990987,0.00006871052,0.000003491787,0.0001660623],"study_design_scores_gemma":[0.0008044102,0.0005347718,0.0008916232,0.00007737481,0.00004049634,0.0002881289,0.00004461928,0.000002820301,0.9961947,0.0009370262,0.00008738536,0.00009671033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983159,0.0005435232,0.0007756958,0.00009366384,0.00002763256,0.000144282,0.00005877802,0.000002240341,0.00003833531],"genre_scores_gemma":[0.9988133,0.000262287,0.0007547436,0.00003148327,0.00007098303,0.000003665045,0.00001430807,0.000007300746,0.00004187211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002904085,"threshold_uncertainty_score":0.3421366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009307174000227441,"score_gpt":0.2262444910825721,"score_spread":0.2169373170823447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}