{"id":"W2094763327","doi":"10.1016/j.bbrc.2010.04.057","title":"Human P-glycoprotein is active when the two halves are clamped together in the closed conformation","year":2010,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Transmembrane domain; Chemistry; Cyclic nucleotide-binding domain; Transmembrane protein; ATP-binding cassette transporter; Linker; P-glycoprotein; Mutant; Nucleotide; Binding site; Biochemistry; Cytoplasm; Plasma protein binding; Stereochemistry; Amino acid; Multiple drug resistance; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003035369,0.0002838319,0.0005039746,0.0001485337,0.0003167131,0.0009679433,0.0003813454,0.0004916935,0.001510395],"category_scores_gemma":[0.0008310125,0.0003041925,0.0002794314,0.0002305601,0.0008746043,0.0006823484,0.0003267521,0.0007558215,0.0005486573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003025442,"about_ca_system_score_gemma":0.000245366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000398897,"about_ca_topic_score_gemma":0.0004107896,"domain_scores_codex":[0.9996494,0.00009255962,0.00002539219,0.00007815567,0.0001017519,0.00005273853],"domain_scores_gemma":[0.9996206,0.0001626724,0.00006420013,0.00004951104,0.00003052906,0.00007251783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006889582,0.00006474752,0.001097794,0.00009807046,0.0000546213,0.0005382791,0.0001287483,0.0001445663,0.9887039,0.001150731,0.0005588891,0.006770793],"study_design_scores_gemma":[0.0003173876,0.0009245526,0.01375179,0.00004786004,0.0001377269,0.004899476,0.0002658388,0.003102414,0.9558915,0.002608929,0.01796445,0.0000879545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926456,0.002434658,0.002365187,0.0002908834,0.000103312,0.00001778975,0.0002010284,0.00006254866,0.001879011],"genre_scores_gemma":[0.9970373,0.0005160626,0.0009019157,0.00008482961,0.00004253404,0.00001401541,0.0004378065,0.00001818644,0.0009472665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510395,"threshold_uncertainty_score":0.005052745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07337809207684576,"score_gpt":0.3923484000275674,"score_spread":0.3189703079507217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}