{"id":"W2094765038","doi":"10.1038/nm920","title":"L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy","year":2003,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Trace Elements in Health","field":"Nursing","cited_by":482,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Hospital for Sick Children; Heart and Stroke Foundation","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Pfizer; American Heart Association","keywords":"Cardiomyopathy; Oxidative stress; Heart failure; Medicine; Internal medicine; Ferroportin; Verapamil; Cardiac function curve; Cardiology; Endocrinology; Pharmacology; Calcium; Anemia; Hepcidin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0015787,0.0004551887,0.0008468258,0.0004187451,0.0001821972,0.0000231259,0.0003195103,0.0006469438,0.00006723405],"category_scores_gemma":[0.002576787,0.0003832826,0.0001265895,0.0007365331,0.0001459729,0.0001733411,0.00004115815,0.001288554,0.00001625273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000805857,"about_ca_system_score_gemma":0.0001944398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000549731,"about_ca_topic_score_gemma":0.0003775746,"domain_scores_codex":[0.9965011,0.0003086183,0.0006905608,0.000789823,0.00077229,0.0009376435],"domain_scores_gemma":[0.9981399,0.0004872051,0.0002200647,0.0006848271,0.0002054522,0.0002625218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01151248,0.001731497,0.1560899,0.0144858,0.0005654513,0.0009018423,0.05674786,0.001027784,0.1217463,0.01292163,0.2847417,0.3375278],"study_design_scores_gemma":[0.01626954,0.003527516,0.006973846,0.001589274,0.0003326592,0.0001264781,0.002945198,0.0001580829,0.05073898,0.003789495,0.9124002,0.001148682],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8787622,0.06508137,0.0003090716,0.01423675,0.03027651,0.006059424,0.00007151417,0.0003755031,0.004827647],"genre_scores_gemma":[0.9915946,0.00009782985,0.002591517,0.002624752,0.002144819,0.0002024207,0.0000888934,0.0001009981,0.0005541455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6276585,"threshold_uncertainty_score":0.9998619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068437010327722,"score_gpt":0.2982892197674069,"score_spread":0.2876048496641297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}