{"id":"W2094779995","doi":"10.1038/jcbfm.2013.154","title":"Rapid and Reversible Enhancement of Blood–Brain Barrier Permeability Using Lysophosphatidic Acid","year":2013,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Lysophosphatidic acid; Blood–brain barrier; Permeability (electromagnetism); Pharmacology; Chemistry; Evans Blue; Biophysics; Autotaxin; Biochemistry; Endocrinology; Medicine; Biology; Central nervous system; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002230505,0.0006205586,0.0003278177,0.0003183523,0.0001174442,0.0003088244,0.0002129091,0.000348332,0.0007729506],"category_scores_gemma":[0.0002247528,0.0001986055,0.0003030514,0.0001444027,0.0002951,0.0005263301,0.0002383519,0.0008262875,0.0003005505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002365538,"about_ca_system_score_gemma":0.0002665572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003116142,"about_ca_topic_score_gemma":0.0004333462,"domain_scores_codex":[0.9998611,0.00003042507,0.00001292904,0.00003534844,0.0000291246,0.00003116376],"domain_scores_gemma":[0.99984,0.00002729794,0.00005832587,0.00002198498,0.00001719335,0.00003523636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001184282,0.00002179143,0.00004259362,0.00003264546,0.0000043171,0.00005615382,0.000007351833,0.00001696883,0.9985864,0.00004453403,0.00001502309,0.001053734],"study_design_scores_gemma":[0.00001128183,0.0004083805,0.0007718242,0.000003671555,0.00001051394,0.000126662,0.000006130762,0.0001597864,0.9978091,0.00002472404,0.0006645357,0.000003471212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829481,0.004294937,0.01053493,0.0001929517,0.00006238613,0.00008899066,0.0002533844,0.0002368589,0.001387478],"genre_scores_gemma":[0.9857637,0.003862263,0.007493536,0.00007895936,0.00003374325,0.0001055023,0.0003374266,0.00003804968,0.002286812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007729506,"threshold_uncertainty_score":0.002585769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009426281871854798,"score_gpt":0.2248109769035195,"score_spread":0.2153846950316647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}