{"id":"W2094795023","doi":"10.1002/pd.2084","title":"Prospective experience with integrated prenatal screening and first trimester combined screening for trisomy 21 in a large Canadian urban center","year":2008,"lang":"en","type":"article","venue":"Prenatal Diagnosis","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto; North York General Hospital; Mount Sinai Hospital","funders":"","keywords":"Trisomy; Prenatal screening; Medicine; Prospective cohort study; Down syndrome; Obstetrics; Nuchal Translucency Measurement; Aneuploidy; Prenatal diagnosis; Pregnancy; Gynecology; Fetus; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001912065,0.0004226145,0.0006048381,0.0004438543,0.0003869481,0.00007313264,0.0002056752,0.0002047153,0.00005387517],"category_scores_gemma":[0.0008369588,0.0003658418,0.0001180744,0.0005680765,0.0002357636,0.0004808728,0.0001277757,0.0004464263,0.000004843888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001734145,"about_ca_system_score_gemma":0.0002274663,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02560322,"about_ca_topic_score_gemma":0.03893545,"domain_scores_codex":[0.9974627,0.00005147378,0.0004463957,0.0007706398,0.0003393597,0.0009293599],"domain_scores_gemma":[0.9980264,0.0006074715,0.000117371,0.0003612615,0.0001889837,0.0006985151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001689375,0.0003679304,0.990021,0.0001290902,0.0001001607,0.0004822862,0.003249755,0.00001535094,0.000002402376,0.00008039964,0.001525454,0.002336754],"study_design_scores_gemma":[0.02078157,0.001725331,0.9599181,0.002902498,0.0001115835,0.0003777137,0.0009702113,0.003834225,0.00411674,0.00001683394,0.004555446,0.0006896787],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990596,0.0008709824,0.003451147,0.0007787851,0.00009203914,0.002559145,0.0009906642,0.0001438691,0.0005173524],"genre_scores_gemma":[0.9895509,0.0001236937,0.007246652,0.0004317686,0.00008773243,0.001607409,0.0006665934,0.00006989005,0.0002153199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03010288,"threshold_uncertainty_score":0.9998794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02114673696404765,"score_gpt":0.25197282791307,"score_spread":0.2308260909490223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}