{"id":"W2094866111","doi":"10.1016/j.jacc.2005.09.038","title":"Chronic Recurrent Myocardial Ischemic Injury Is Significantly Attenuated by Pre-Emptive Adeno-Associated Virus Heme Oxygenase-1 Gene Delivery","year":2006,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada; Edna and Fred L. Mandel, Jr. Foundation","keywords":"Medicine; Ischemia; Heme oxygenase; Adeno-associated virus; Reperfusion injury; Fibrosis; Cardiology; Gene delivery; Cardiac function curve; Myocardial fibrosis; Genetic enhancement; Heart failure; Internal medicine; Pharmacology; Heme; Gene; Enzyme; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004120551,0.0006830713,0.0009001893,0.0003278742,0.0002527538,0.0006551828,0.000428635,0.0005709736,0.002652497],"category_scores_gemma":[0.0003525944,0.0002930561,0.0004216519,0.0002049319,0.0006491232,0.000453861,0.0002525125,0.001555597,0.0006098857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002762048,"about_ca_system_score_gemma":0.0003696122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006110284,"about_ca_topic_score_gemma":0.0009784083,"domain_scores_codex":[0.9997274,0.00004138874,0.00002396281,0.00003590971,0.00004184309,0.0001294595],"domain_scores_gemma":[0.9996141,0.00004489682,0.0001307116,0.00005085138,0.00002416647,0.0001352744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00232739,0.0004546547,0.0002017285,0.00007846635,0.00002202761,0.000127739,0.00004425192,0.00004840233,0.99363,0.0002332897,0.0001603988,0.002671539],"study_design_scores_gemma":[0.0008979763,0.006584225,0.01198979,0.00003412499,0.0001522449,0.0006831037,0.0001319954,0.00188255,0.9746556,0.0001652276,0.002800701,0.00002248548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954525,0.001304566,0.00174021,0.0002150306,0.0001171933,0.0000357341,0.0001684305,0.0001563467,0.0008100263],"genre_scores_gemma":[0.9939436,0.0007213484,0.001256775,0.00007973683,0.00005320196,0.00007868741,0.0003842278,0.00003716395,0.003445094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002652497,"threshold_uncertainty_score":0.008873463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005185083135234551,"score_gpt":0.2264920815472104,"score_spread":0.2213069984119759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}