{"id":"W2094866111","doi":"10.1016/j.jacc.2005.09.038","title":"Chronic Recurrent Myocardial Ischemic Injury Is Significantly Attenuated by Pre-Emptive Adeno-Associated Virus Heme Oxygenase-1 Gene Delivery","year":2006,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada; Edna and Fred L. Mandel, Jr. Foundation","keywords":"Medicine; Ischemia; Heme oxygenase; Adeno-associated virus; Reperfusion injury; Fibrosis; Cardiology; Gene delivery; Cardiac function curve; Myocardial fibrosis; Genetic enhancement; Heart failure; Internal medicine; Pharmacology; Heme; Gene; Enzyme; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005023294,0.0003357571,0.0009879175,0.0001042209,0.0001002381,0.000008876335,0.0006575566,0.0002205082,0.00001026115],"category_scores_gemma":[0.0001349699,0.0002666996,0.0008671341,0.000392859,0.0005505594,0.00001033746,0.0001992808,0.0003708619,0.000003515769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222849,"about_ca_system_score_gemma":0.0006222802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009923872,"about_ca_topic_score_gemma":0.00002918969,"domain_scores_codex":[0.9972767,0.000581238,0.0008807672,0.0003767571,0.000389468,0.0004950228],"domain_scores_gemma":[0.9973757,0.00005645806,0.001446927,0.0005031896,0.0004818615,0.0001358254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007198042,0.0000503572,0.002139569,0.000006365617,0.000758119,0.00002597865,0.000009558596,0.0002353422,0.8012924,0.000001846691,0.1944555,0.0003051651],"study_design_scores_gemma":[0.001425775,0.002546944,0.0123309,0.00003805404,0.0003318535,0.0002278889,0.0001238122,0.00003125724,0.9177041,0.00003216585,0.06480322,0.0004040256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992525,0.004237746,0.0001748612,0.0004432382,0.000444835,0.0002535235,0.001510898,0.000008139542,0.0004017976],"genre_scores_gemma":[0.9965742,0.00121575,0.00009317083,0.0003918282,0.001185396,0.00001285676,0.00005826636,0.00004582941,0.0004226995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1296523,"threshold_uncertainty_score":0.9999785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005185083135234551,"score_gpt":0.2264920815472104,"score_spread":0.2213069984119759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}