{"id":"W2094972225","doi":"10.1038/nsmb.2893","title":"The RNA exosome promotes transcription termination of backtracked RNA polymerase II","year":2014,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Wellcome Trust","keywords":"RNA polymerase II; Exosome complex; Transcription (linguistics); RNA; Cell biology; Termination factor; Biology; Exosome; Molecular biology; Genetics; Non-coding RNA; Gene expression; Gene; Promoter; microRNA; Microvesicles","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027705,0.0002052989,0.0001960897,0.0000639732,0.0002596353,0.00002150652,0.000382394,0.0005072006,0.0000117869],"category_scores_gemma":[0.0003292955,0.0001375538,0.0001596095,0.0001285224,0.000263182,0.000006904083,0.00009322019,0.0003797534,0.000001368723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001325264,"about_ca_system_score_gemma":0.00004710662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002451604,"about_ca_topic_score_gemma":0.00002142469,"domain_scores_codex":[0.9985281,0.0002571087,0.0002749923,0.0003789533,0.000169858,0.0003909519],"domain_scores_gemma":[0.9991715,0.00002437411,0.0001351732,0.0004075197,0.0001719035,0.00008951728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001220743,0.000008820409,0.00008979348,0.00001398814,0.00004933236,0.000001590347,0.00001997207,0.000003783253,0.9651287,0.003571546,0.00007742333,0.03091299],"study_design_scores_gemma":[0.0005447886,0.0006818784,0.00189478,0.000009646023,0.00001550457,0.00002237971,0.00001449942,0.0003045917,0.9920543,0.00200598,0.002287785,0.0001638603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946325,0.0023579,0.0008998757,0.001206596,0.00026503,0.000270815,0.00002099005,0.00001317451,0.0003330999],"genre_scores_gemma":[0.9984031,0.00007108238,0.000423113,0.0003036754,0.0001879798,0.00001440406,0.0002379895,0.00002064182,0.0003379991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03074913,"threshold_uncertainty_score":0.5609283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003778474963522496,"score_gpt":0.2826724765730537,"score_spread":0.2788940016095312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}