{"id":"W2094984709","doi":"10.1016/j.ymthe.2006.08.1009","title":"919. Gene Therapy for Duchenne Muscular Dystrophy Using a Gutted Adenovirus Expressing Utrophin","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Christie (Canada); Biotechnology Research Institute; Montreal Neurological Institute and Hospital","funders":"","keywords":"Duchenne muscular dystrophy; Utrophin; Dystrophin; Muscular dystrophy; Sarcolemma; mdx mouse; Transgene; Genetic enhancement; Biology; Gene; Medicine; Molecular biology; Genetics; Cell biology; Myocyte","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004565718,0.0005525715,0.0004209459,0.0001993532,0.0003378468,0.0001618048,0.0006331668,0.0003573385,0.00004772426],"category_scores_gemma":[0.00002768736,0.00053399,0.0005069215,0.0003231261,0.0001936165,0.00001467046,0.00008882134,0.0002095194,0.00001218152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007566674,"about_ca_system_score_gemma":0.0002085714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001468805,"about_ca_topic_score_gemma":0.00001547053,"domain_scores_codex":[0.9967844,0.0003122649,0.000481726,0.0009910065,0.0004902635,0.0009402905],"domain_scores_gemma":[0.9981746,0.00002138793,0.0001874822,0.001146314,0.0003072849,0.0001629155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004537483,0.0003047417,0.00009602233,0.00001183808,0.0002747343,0.00004428946,0.00002828238,0.002581003,0.9822264,0.00003387043,0.0003075455,0.009553835],"study_design_scores_gemma":[0.005432813,0.002408402,0.0001671235,0.00001540814,0.00001839927,0.00002880308,0.0000139873,0.000956882,0.969707,0.0004118088,0.02022563,0.0006137177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9376282,0.01875137,0.04183061,0.0001793089,0.0001481568,0.001251375,0.00006371123,0.00008643103,0.00006082938],"genre_scores_gemma":[0.9869304,0.0008549995,0.00934747,0.0009798269,0.0008057348,0.0002626628,0.0003840327,0.0002540745,0.0001808337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04930216,"threshold_uncertainty_score":0.9997112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02412610005721989,"score_gpt":0.2978730644726321,"score_spread":0.2737469644154122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}