{"id":"W2094984709","doi":"10.1016/j.ymthe.2006.08.1009","title":"919. Gene Therapy for Duchenne Muscular Dystrophy Using a Gutted Adenovirus Expressing Utrophin","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Christie (Canada); Biotechnology Research Institute; Montreal Neurological Institute and Hospital","funders":"","keywords":"Duchenne muscular dystrophy; Utrophin; Dystrophin; Muscular dystrophy; Sarcolemma; mdx mouse; Transgene; Genetic enhancement; Biology; Gene; Medicine; Molecular biology; Genetics; Cell biology; Myocyte","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001980729,0.0005977052,0.000266774,0.0005529135,0.0002825214,0.0002639428,0.0003303627,0.0006439212,0.01092514],"category_scores_gemma":[0.0000869769,0.0001809076,0.0004022572,0.0002136487,0.0002020485,0.0001908032,0.0002475749,0.0008898324,0.005147783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003522203,"about_ca_system_score_gemma":0.0003768067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009997907,"about_ca_topic_score_gemma":0.001532497,"domain_scores_codex":[0.9998627,0.0000231029,0.00001447517,0.00002813563,0.0000465103,0.00002520662],"domain_scores_gemma":[0.9999454,0.00001356116,0.000008608676,0.000006982863,0.000008279221,0.00001722974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000476503,0.0004565335,0.0002655526,0.0002746246,0.00002563515,0.0005500033,0.00005743493,0.0002202306,0.9464582,0.002531611,0.003960647,0.04472298],"study_design_scores_gemma":[0.0003797855,0.002935451,0.005283065,0.0001101733,0.0001066468,0.003466657,0.00005248194,0.001574809,0.7283438,0.0004709238,0.2572367,0.0000394592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6201907,0.0361592,0.08171374,0.003594457,0.003985712,0.002658958,0.01318707,0.002646532,0.2358637],"genre_scores_gemma":[0.618073,0.02427797,0.07304816,0.001047254,0.0002261377,0.001378519,0.01816228,0.0002743928,0.2635122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01092514,"threshold_uncertainty_score":0.03654826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02412610005721989,"score_gpt":0.2978730644726321,"score_spread":0.2737469644154122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}