{"id":"W2095060147","doi":"10.1186/1471-2172-12-22","title":"Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature","year":2011,"lang":"en","type":"article","venue":"BMC Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Krembil Foundation; Women's College Hospital; Canadian Institutes of Health Research; Terry Fox Foundation; Ontario HIV Treatment Network","keywords":"Cytotoxic T cell; Biology; IL-2 receptor; Cell biology; CD8; Haematopoiesis; Interleukin 21; Stem cell; Antigen-presenting cell; T cell; CD38; Granzyme B; Natural killer T cell; Immunology; Immune system; In vitro; CD34","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002534968,0.0006311376,0.00100862,0.0004238758,0.0003452571,0.00002417927,0.0008913119,0.001648059,0.004796543],"category_scores_gemma":[0.00001128604,0.0005974882,0.0002596114,0.0003597269,0.0006848737,0.0001450592,0.0003726475,0.001336255,0.005869518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001360398,"about_ca_system_score_gemma":0.0001442923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009568578,"about_ca_topic_score_gemma":0.0003937508,"domain_scores_codex":[0.9959917,0.0008596143,0.0009527968,0.001009012,0.00006585438,0.001121022],"domain_scores_gemma":[0.9981147,0.0001786861,0.0004834516,0.001039136,0.000142613,0.00004143591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009324333,0.0007178654,0.001098115,0.00002552347,0.0004142041,0.00008005757,0.0009654511,0.000006411314,0.9922056,0.0005838317,0.002700963,0.0002696007],"study_design_scores_gemma":[0.003587506,0.0002610774,0.006390477,0.00004252224,0.00008738579,0.0001190025,0.001219653,0.000002944493,0.9767272,0.0005838217,0.01036261,0.0006157315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814329,0.01122827,0.0001431556,0.00006698892,0.004395931,0.0004611047,0.000144024,0.000288572,0.001839053],"genre_scores_gemma":[0.9860004,0.0001169454,0.0003879548,0.0003382488,0.00007860985,0.0001046194,0.0003641492,0.00008159199,0.01252747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01547827,"threshold_uncertainty_score":0.999648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02234663692798441,"score_gpt":0.204034914007638,"score_spread":0.1816882770796536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}