{"id":"W2095060147","doi":"10.1186/1471-2172-12-22","title":"Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature","year":2011,"lang":"en","type":"article","venue":"BMC Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Krembil Foundation; Women's College Hospital; Canadian Institutes of Health Research; Terry Fox Foundation; Ontario HIV Treatment Network","keywords":"Cytotoxic T cell; Biology; IL-2 receptor; Cell biology; CD8; Haematopoiesis; Interleukin 21; Stem cell; Antigen-presenting cell; T cell; CD38; Granzyme B; Natural killer T cell; Immunology; Immune system; In vitro; CD34","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002087081,0.0003367124,0.0001768939,0.0001439879,0.00007952894,0.0003160733,0.0001609933,0.0002502436,0.003492983],"category_scores_gemma":[0.0001700176,0.000104405,0.000128709,0.0001241383,0.000138911,0.0001186842,0.0002046911,0.0005589547,0.001466891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000107729,"about_ca_system_score_gemma":0.000124471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001192253,"about_ca_topic_score_gemma":0.0001398642,"domain_scores_codex":[0.9998509,0.00002769741,0.00001921473,0.00003182873,0.00004936034,0.00002109963],"domain_scores_gemma":[0.9998624,0.00002944867,0.00002582368,0.00002662329,0.00002675513,0.0000289404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001892114,0.0000453494,0.0003442463,0.00007994708,0.00000524044,0.00007821518,0.00003423211,0.00008518629,0.994361,0.0001422679,0.0001718198,0.004463309],"study_design_scores_gemma":[0.00008161719,0.000696848,0.003101487,0.00002747932,0.00003584349,0.0007488517,0.00002906351,0.0008470312,0.9798118,0.0001680454,0.01444709,0.000004812257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.958279,0.004020276,0.02646227,0.0002109715,0.0001476133,0.0003363864,0.001800985,0.0004250547,0.00831737],"genre_scores_gemma":[0.9802316,0.001225403,0.008616854,0.0001244607,0.00005409435,0.0001603117,0.003345645,0.00006638248,0.006175328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003492983,"threshold_uncertainty_score":0.01168519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02234663692798441,"score_gpt":0.204034914007638,"score_spread":0.1816882770796536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}