{"id":"W2095069199","doi":"10.1002/jgm.1261","title":"Lentivirus gene therapy for purine nucleoside phosphorylase deficiency","year":2008,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Jeffrey Modell Foundation","keywords":"Purine nucleoside phosphorylase; Genetic enhancement; Biology; Molecular biology; Transduction (biophysics); Bone marrow; Viral vector; Cancer research; Purine; Immunology; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007432455,0.000138894,0.0002112191,0.00004901544,0.0001476006,0.000003663447,0.0004175094,0.00007693057,0.00004069618],"category_scores_gemma":[0.0002014617,0.00007621689,0.0001356216,0.0001076612,0.000329865,0.000002990772,0.00005465063,0.0001568801,0.000003541626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001238589,"about_ca_system_score_gemma":0.000112426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001800803,"about_ca_topic_score_gemma":0.000001857492,"domain_scores_codex":[0.998859,0.0000720319,0.0003364854,0.0001361565,0.0003346998,0.0002615873],"domain_scores_gemma":[0.9990839,0.00003652473,0.0001752661,0.0002868659,0.0002855441,0.0001319374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009132213,0.0001000188,0.0001170917,0.000006857604,0.00006027989,0.00001955596,0.00008897866,0.000009522076,0.9807581,0.000006026791,0.01384392,0.004076411],"study_design_scores_gemma":[0.002127147,0.001956557,0.0007331638,0.00001292245,0.00003086996,0.0007850527,0.00004486878,0.000008837873,0.9564924,0.00008162574,0.03763638,0.00009012866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9568618,0.03345472,0.007042911,0.002055421,0.0001617152,0.000211665,0.000005573055,0.000003116077,0.0002030903],"genre_scores_gemma":[0.9815971,0.01531111,0.0007719777,0.0007738821,0.0008577404,0.000005757061,0.00001461528,0.00002378163,0.0006440381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0247353,"threshold_uncertainty_score":0.3108034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03067185941448462,"score_gpt":0.2924146917662501,"score_spread":0.2617428323517654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}