{"id":"W2095069199","doi":"10.1002/jgm.1261","title":"Lentivirus gene therapy for purine nucleoside phosphorylase deficiency","year":2008,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Jeffrey Modell Foundation","keywords":"Purine nucleoside phosphorylase; Genetic enhancement; Biology; Molecular biology; Transduction (biophysics); Bone marrow; Viral vector; Cancer research; Purine; Immunology; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003382094,0.0004207854,0.0003479042,0.0004226017,0.0001942091,0.0004193941,0.0003462558,0.0005497023,0.001118012],"category_scores_gemma":[0.0002262816,0.0001090969,0.0002997263,0.0001977674,0.0002965491,0.0002607183,0.000272601,0.0007844211,0.0002833461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002991534,"about_ca_system_score_gemma":0.0002715134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002769838,"about_ca_topic_score_gemma":0.0002443339,"domain_scores_codex":[0.9998086,0.00004201375,0.0000180215,0.00003035948,0.00006683728,0.00003414981],"domain_scores_gemma":[0.9998674,0.00003136187,0.00003834957,0.00002137874,0.00001302292,0.00002848168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002088365,0.0003394125,0.0007829989,0.0001850996,0.00003362511,0.0003829051,0.00004745877,0.0002195371,0.9804856,0.0007352753,0.0006651711,0.015914],"study_design_scores_gemma":[0.0002950687,0.003034566,0.004605679,0.00008217849,0.0001915633,0.005279027,0.00005570198,0.003545783,0.9572933,0.0004131822,0.02518032,0.00002356823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465947,0.01190593,0.03387607,0.0003910477,0.0002629347,0.0005327828,0.001023462,0.0007041632,0.004708881],"genre_scores_gemma":[0.9747293,0.006671869,0.01158629,0.0002133514,0.00007737629,0.0005296883,0.001952378,0.0001152327,0.004124544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001118012,"threshold_uncertainty_score":0.003740072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03067185941448462,"score_gpt":0.2924146917662501,"score_spread":0.2617428323517654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}