{"id":"W2095070050","doi":"10.1007/s00335-011-9351-5","title":"Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation","year":2011,"lang":"en","type":"article","venue":"Mammalian Genome","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University; Montreal Children's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Human genetics; Promoter; Genetics; Methylenetetrahydrofolate reductase; Computational biology; Gene; Genotype; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003630992,0.0001017353,0.0002211002,0.0002813444,0.00002460489,0.00000767617,0.00006309458,0.00007707789,0.0003691974],"category_scores_gemma":[0.00001774592,0.00009264857,0.00002534524,0.0003214409,0.00007182125,0.0001026999,0.00003263356,0.0001171361,0.0000371266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005621383,"about_ca_system_score_gemma":0.00002678081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003831771,"about_ca_topic_score_gemma":0.00005750201,"domain_scores_codex":[0.9989905,0.00006408185,0.0003113165,0.0002320737,0.0001895817,0.000212443],"domain_scores_gemma":[0.9995329,0.000009194257,0.00007464306,0.0002108143,0.00007697661,0.00009546823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003316362,0.0001239644,0.06399978,0.0001695737,0.00001586813,0.00005705246,0.0019386,7.157112e-7,0.9278445,0.0001094214,0.0001158417,0.00529303],"study_design_scores_gemma":[0.001396109,0.0005041203,0.9326755,0.00008034443,0.0000125498,0.00002769634,0.0001253405,0.00004566986,0.06168658,0.0004095597,0.002923029,0.0001134826],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965174,0.0005398504,0.0000458118,0.0002097713,0.00003143549,0.0005214012,0.000006238244,0.00001836271,0.002109698],"genre_scores_gemma":[0.9947376,0.00005887851,0.002081094,0.00003157341,0.000044303,0.00001147195,0.00005762093,0.00001849256,0.00295894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8686757,"threshold_uncertainty_score":0.4042453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04607847816344082,"score_gpt":0.2844989365990329,"score_spread":0.238420458435592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}