{"id":"W2095083583","doi":"10.1074/jbc.m401027200","title":"The Intrinsic Threshold of the Fibrinolytic System Is Modulated by Basic Carboxypeptidases, but the Magnitude of the Antifibrinolytic Effect of Activated Thrombin-activable Fibrinolysis Inhibitor Is Masked by Its Instability","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Carboxypeptidase; Fibrinolysis; Plasmin; Chemistry; Lysis; Biophysics; Thrombin; Antifibrinolytic; Biochemistry; Internal medicine; Enzyme; Biology; Medicine; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003613418,0.0003286015,0.0003634683,0.0002013944,0.0001190548,0.0005437484,0.0002197603,0.0003482477,0.0005896622],"category_scores_gemma":[0.0005091769,0.0001795992,0.000248752,0.0001804434,0.0003559171,0.000295969,0.0002187477,0.0006126515,0.0002172447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003412812,"about_ca_system_score_gemma":0.0002422284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002826101,"about_ca_topic_score_gemma":0.0001981111,"domain_scores_codex":[0.9996401,0.0000690759,0.00004152148,0.00007068857,0.0001228226,0.00005579897],"domain_scores_gemma":[0.9995933,0.0001179373,0.0001322417,0.00003943697,0.0000556091,0.00006144692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003779352,0.000005480248,0.0001256641,0.00001531807,0.000003627291,0.00001393694,0.00000550218,0.00001735591,0.9992495,0.00004256009,0.00000488312,0.0004784603],"study_design_scores_gemma":[0.000005111517,0.0001313271,0.005306494,0.000003651831,0.000007279814,0.0001664814,0.000007469698,0.0003383258,0.9936034,0.00006480284,0.00036155,0.00000414207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860439,0.003692491,0.008811688,0.0000883819,0.00001847368,0.00002464352,0.0001559436,0.0000498838,0.001114527],"genre_scores_gemma":[0.9941725,0.001043009,0.004074744,0.00003790798,0.00001455599,0.00003565907,0.0001593721,0.00001526009,0.0004469219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005896622,"threshold_uncertainty_score":0.002476156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497621474783068,"score_gpt":0.2358121127018364,"score_spread":0.2208358979540058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}