{"id":"W2095103987","doi":"10.1016/j.bmcl.2006.07.074","title":"Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Benzimidazole; Chemistry; Replicon; Allosteric regulation; Hepatitis C virus; RNA polymerase; Polymerase; Indole test; Stereochemistry; Virology; Enzyme; Biochemistry; Virus; RNA; Biology; Hepacivirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591432,0.0002593689,0.0002021628,0.0001454767,0.0001379612,0.0002367576,0.0002716499,0.0001822936,0.001382842],"category_scores_gemma":[0.000127356,0.0001035734,0.0001773336,0.0001263079,0.0001366382,0.000178848,0.0001353298,0.0003716583,0.0003091016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003724683,"about_ca_system_score_gemma":0.0002059795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001504999,"about_ca_topic_score_gemma":0.003511897,"domain_scores_codex":[0.9999433,0.000009616279,0.00000424485,0.000008495244,0.00001028699,0.0000241121],"domain_scores_gemma":[0.9999566,0.00001157046,0.000008536111,0.000007634532,0.000006280899,0.000009290831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003158827,0.00007848429,0.0001094812,0.00005436723,0.000003935676,0.00007272227,0.0000392753,0.0004277786,0.9929582,0.0002937423,0.0001417093,0.005504468],"study_design_scores_gemma":[0.00004457391,0.0006058111,0.0009634386,0.00000455793,0.00001494186,0.00007677701,0.000009712712,0.001046127,0.9951095,0.00003030822,0.002087442,0.000006805949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900919,0.002058537,0.003249243,0.0001315661,0.00004026082,0.00003563994,0.0002540191,0.0002123429,0.003926395],"genre_scores_gemma":[0.995833,0.0007215172,0.001334212,0.00002865609,0.000007958373,0.00001265292,0.0002696483,0.00001748827,0.001774952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504999,"threshold_uncertainty_score":0.004626036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008459677690689796,"score_gpt":0.2462839894662787,"score_spread":0.2378243117755889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}