{"id":"W2095130233","doi":"10.1007/s00125-012-2539-8","title":"Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity","year":2012,"lang":"en","type":"article","venue":"Diabetologia","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":210,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Key Research and Development Program of China; Shanghai Xuhui District Central Hospital; Directorate for Biological Sciences; Chinese Academy of Sciences; China Postdoctoral Science Foundation; National Natural Science Foundation of China; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Program of Shanghai Subject Chief Scientist; Ottawa Hospital Research Institute","keywords":"Sirtuin 1; Insulin resistance; Downregulation and upregulation; Biology; Insulin; Endocrinology; Internal medicine; microRNA; Biochemistry; Medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003187487,0.0005187475,0.0009391933,0.0004663757,0.0003606829,0.0006696816,0.0003654679,0.0004751237,0.002675046],"category_scores_gemma":[0.0003458834,0.0004083906,0.0006519256,0.0003013027,0.0004585028,0.0004828053,0.0003285053,0.001485685,0.001019377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003596039,"about_ca_system_score_gemma":0.0003252252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003902821,"about_ca_topic_score_gemma":0.0006121131,"domain_scores_codex":[0.999696,0.00006109713,0.00003979527,0.00006255579,0.00007596919,0.00006468448],"domain_scores_gemma":[0.9997881,0.00003249333,0.00006020038,0.0000377553,0.0000308029,0.0000506766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004091538,0.000483046,0.0007438095,0.0001869274,0.00008557084,0.0001135306,0.00005092564,0.0001540939,0.9813125,0.0003374534,0.0005908791,0.01184985],"study_design_scores_gemma":[0.0006238464,0.00296439,0.009355327,0.00001954471,0.0002900856,0.0005294046,0.0001627907,0.00227516,0.9718544,0.0004523222,0.01143557,0.00003708732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805899,0.005950164,0.005654518,0.0008806861,0.0007854936,0.00005390793,0.0004415619,0.0009172282,0.004726544],"genre_scores_gemma":[0.99328,0.001124798,0.00223818,0.0002620833,0.00008145608,0.00003455511,0.0004005549,0.00007561246,0.002502757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002675046,"threshold_uncertainty_score":0.008948982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112728443254759,"score_gpt":0.2539726153689519,"score_spread":0.2428453309364043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}