{"id":"W2095130514","doi":"10.1110/ps.0241403","title":"Unique stabilizing interactions identified in the two‐stranded α‐helical coiled‐coil: Crystal structure of a cortexillin I/GCN4 hybrid coiled‐coil peptide","year":2003,"lang":"en","type":"article","venue":"Protein Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Fondation pour la Recherche Médicale; National Science Foundation; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Coiled coil; Crystallography; Peptide; Salt bridge; Hydrogen bond; Chemistry; Protein folding; Hydrophobic effect; Leucine zipper; Folding (DSP implementation); Macromolecule; Stereochemistry; Biophysics; Peptide sequence; Molecule; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000795002,0.0002875298,0.0002352852,0.0001503415,0.0001772351,0.0002627511,0.0002352858,0.0002261785,0.0007201192],"category_scores_gemma":[0.0002261368,0.0001482924,0.0001561827,0.0001356608,0.0002684946,0.0001268853,0.0001813003,0.000291043,0.0001370299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003025635,"about_ca_system_score_gemma":0.0001936998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008727034,"about_ca_topic_score_gemma":0.001043777,"domain_scores_codex":[0.9999394,0.000006854628,0.000003057638,0.00001671761,0.00001980787,0.00001406224],"domain_scores_gemma":[0.9998872,0.00002207031,0.00003295529,0.000004134984,0.00001348363,0.00004016184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002025312,0.00004421666,0.005561283,0.0001106312,0.00003308537,0.0008001156,0.00009872804,0.002664056,0.9867093,0.0002370586,0.0001048104,0.003434196],"study_design_scores_gemma":[0.0002776469,0.0006761368,0.08793984,0.00004865613,0.0001547377,0.003064516,0.0004188203,0.03611737,0.864031,0.0007475906,0.006451136,0.00007257103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986247,0.0001863512,0.0006466654,0.00001219523,0.000003162404,0.000007657811,0.00003440047,0.0000158651,0.0004689842],"genre_scores_gemma":[0.9979959,0.00007555506,0.001476863,0.00001515753,0.000002367464,0.00001134765,0.0001840171,0.000005852046,0.000233008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008727034,"threshold_uncertainty_score":0.002409041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184226690845729,"score_gpt":0.2745337600032752,"score_spread":0.2626914930948179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}