{"id":"W2095180356","doi":"10.1074/jbc.m111.319020","title":"Sequence Variation in Promoter of Ica1 Gene, Which Encodes Protein Implicated in Type 1 Diabetes, Causes Transcription Factor Autoimmune Regulator (AIRE) to Increase Its Binding and Down-regulate Expression","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; U.S. Public Health Service","keywords":"Nod; Biology; Autoimmune regulator; NOD mice; Transfection; Transcription factor; Molecular biology; Gene; Enhancer; Transcriptional regulation; Regulatory sequence; Regulation of gene expression; Gene expression; Promoter; Luciferase; Reporter gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285716,0.0002967089,0.0001482149,0.0002270468,0.00009204057,0.0001426123,0.0001441461,0.0001941878,0.0018445],"category_scores_gemma":[0.0001937738,0.00009750272,0.0003201115,0.0001636965,0.0001906533,0.00006061902,0.0001449469,0.0005183269,0.0004829839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001726715,"about_ca_system_score_gemma":0.0001383584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004260578,"about_ca_topic_score_gemma":0.0007252428,"domain_scores_codex":[0.9998475,0.00003025349,0.00001492279,0.00005372887,0.00003263511,0.00002095348],"domain_scores_gemma":[0.9998161,0.00005255908,0.00007019264,0.00001428036,0.00001430302,0.00003250701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009767537,0.00001985753,0.001124605,0.00003205247,0.000006854134,0.00009610906,0.00001991795,0.00006186011,0.9970925,0.00007617455,0.00004039073,0.001331861],"study_design_scores_gemma":[0.00008387256,0.0004239243,0.09070037,0.00006534164,0.0001166289,0.003044307,0.00009988022,0.00353181,0.8902292,0.0002305791,0.01145039,0.0000237216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887377,0.001257728,0.007578366,0.0001225739,0.00006217232,0.00002643127,0.001162909,0.0001176851,0.0009346082],"genre_scores_gemma":[0.9917868,0.0005265533,0.003998196,0.00008717665,0.00002183354,0.00004017569,0.001836013,0.00004201203,0.001661244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0018445,"threshold_uncertainty_score":0.006170452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01903601027513965,"score_gpt":0.250114408794808,"score_spread":0.2310783985196683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}