{"id":"W2095202886","doi":"10.1038/cdd.2010.187","title":"CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression","year":2011,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Office of Science; National Cancer Institute; National Institutes of Health; Newcastle University; University of Oregon; McGill University","keywords":"Biology; Carcinogenesis; Neural crest; Neuroblastoma; Loss of heterozygosity; Cancer research; Epigenetics; Reprogramming; Transcription factor; Cell fate determination; Zinc finger; Gene expression; Enhancer; Zinc finger transcription factor; Tumor suppressor gene; Gene expression profiling; Cell biology; Gene; Genetics; Cell culture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232479,0.0003541389,0.0003382333,0.0004702423,0.0002444814,0.0003391215,0.0003288829,0.0002732281,0.001327398],"category_scores_gemma":[0.0001413545,0.0001320473,0.0002092461,0.0002149658,0.0003429959,0.0001573417,0.0001655925,0.0005746938,0.0003204009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005699875,"about_ca_system_score_gemma":0.0003818432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077194,"about_ca_topic_score_gemma":0.002039331,"domain_scores_codex":[0.9998658,0.00001184819,0.00001081258,0.00003394744,0.00004891524,0.00002875573],"domain_scores_gemma":[0.9999195,0.00001881124,0.00002386489,0.000008516295,0.000007316909,0.00002202648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191738,0.00002147151,0.0002034279,0.00001993536,0.000004213179,0.00005737006,0.000007963294,0.00007815546,0.9973347,0.0002416326,0.00009514745,0.00181696],"study_design_scores_gemma":[0.00002504665,0.00008755815,0.001699643,0.000002254727,0.00001566356,0.0002772172,0.00001870966,0.001145226,0.9937597,0.00006938115,0.002896116,0.000003527291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876719,0.002128458,0.00445308,0.0003309947,0.0001102401,0.00004057643,0.0006803165,0.000337388,0.004247081],"genre_scores_gemma":[0.9932933,0.0006498935,0.001639396,0.000046697,0.000009798413,0.00002026234,0.0004888913,0.00003924665,0.00381256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327398,"threshold_uncertainty_score":0.004440606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02753566293484423,"score_gpt":0.2549909809669525,"score_spread":0.2274553180321083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}