{"id":"W2095255852","doi":"10.1182/blood-2008-07-166439","title":"Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; St. Michael's Hospital","funders":"","keywords":"Medicine; Syk; Cytopenia; Refractory (planetary science); Thrombocytopenic purpura; Internal medicine; Platelet; Gastroenterology; Toxicity; Autoimmune hemolytic anemia; Immunology; Anemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006161036,0.0001568164,0.0007773438,0.0000484813,0.00005208405,0.000004748094,0.0001038701,0.00003359612,0.00001113074],"category_scores_gemma":[0.000009818028,0.0001189441,0.0000263871,0.00008538928,0.00007696808,0.0001317761,0.00003746553,0.00001955991,4.618006e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000155563,"about_ca_system_score_gemma":0.00006707541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009072525,"about_ca_topic_score_gemma":0.00005995724,"domain_scores_codex":[0.9990653,0.00003273329,0.0003806127,0.0002395489,0.000138573,0.0001432702],"domain_scores_gemma":[0.999306,0.00003336073,0.0001813596,0.0003156131,0.00008244968,0.00008122245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002274189,0.1928277,0.03359056,0.0001197704,0.001464192,0.00008728336,0.002199577,1.603822e-7,0.7652818,0.00002555727,0.0001006619,0.002028501],"study_design_scores_gemma":[0.1170951,0.2173724,0.05539893,0.00006584969,0.001606788,0.0001334451,0.001465216,0.0000216199,0.6065378,0.00004598631,0.00006935782,0.0001875308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955674,0.001799646,0.000001649883,0.00004337517,0.0000173874,0.002180805,0.0001422955,0.000008643664,0.0002388319],"genre_scores_gemma":[0.9985144,0.0003850143,0.0006712466,0.00000870685,0.00001108314,0.00009374412,0.00009853899,0.00002171039,0.0001955532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.158744,"threshold_uncertainty_score":0.4850399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06270308419405138,"score_gpt":0.3229006111517533,"score_spread":0.2601975269577019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}