{"id":"W2095256902","doi":"10.1002/ddr.1151","title":"Synthesis of 1‐(2‐deoxy‐β‐<scp>D</scp>‐ribofuranosyl)‐2,4‐ difluoro‐5‐(2‐halo‐1‐hydroxyethyl)benzenes and related derivatives: “thymine replacement” analogs of deoxythymidine for evaluation as antiviral and anticancer agents","year":2001,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Thymidine kinase; Chemistry; Varicella zoster virus; Herpes simplex virus; Nucleoside analogue; Thymidine; Thymine; Stereochemistry; Virus; Nucleoside; Virology; Biochemistry; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138449,0.0002656157,0.0001897259,0.00009462724,0.00009136165,0.0001523459,0.0001839008,0.0001939709,0.001261178],"category_scores_gemma":[0.00009547098,0.00009790839,0.000121463,0.0001194002,0.00008615127,0.0001265102,0.00009583063,0.0002239914,0.0004229282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002496878,"about_ca_system_score_gemma":0.0002103054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007200595,"about_ca_topic_score_gemma":0.001353587,"domain_scores_codex":[0.9999231,0.00001833874,0.00000722001,0.00001579483,0.00001600836,0.00001950111],"domain_scores_gemma":[0.999944,0.000004790365,0.00001435999,0.000006107938,0.000008420431,0.00002231423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008182255,0.00001986059,0.00005259867,0.00003945196,0.000003038665,0.00003525809,0.00001191412,0.0001992001,0.9979153,0.0001020524,0.00003449156,0.001504982],"study_design_scores_gemma":[0.00002744419,0.0006768189,0.0009235745,0.000005182043,0.00001221108,0.0001624755,0.000009930095,0.0004954264,0.9935293,0.00001561928,0.004135441,0.000006595745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862416,0.002440188,0.006572843,0.00004785526,0.00005250817,0.0001277506,0.001069882,0.0001283226,0.003319049],"genre_scores_gemma":[0.9867208,0.001087568,0.008663005,0.00004522631,0.000009068375,0.00005746095,0.0009408232,0.00002063106,0.002455456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001261178,"threshold_uncertainty_score":0.004219055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06472119977396813,"score_gpt":0.3916399284627838,"score_spread":0.3269187286888157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}