{"id":"W2095256902","doi":"10.1002/ddr.1151","title":"Synthesis of 1‐(2‐deoxy‐β‐<scp>D</scp>‐ribofuranosyl)‐2,4‐ difluoro‐5‐(2‐halo‐1‐hydroxyethyl)benzenes and related derivatives: “thymine replacement” analogs of deoxythymidine for evaluation as antiviral and anticancer agents","year":2001,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Thymidine kinase; Chemistry; Varicella zoster virus; Herpes simplex virus; Nucleoside analogue; Thymidine; Thymine; Stereochemistry; Virus; Nucleoside; Virology; Biochemistry; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006566381,0.0003446782,0.0008766329,0.001118392,0.0003619498,0.00005766291,0.0002442477,0.0002148975,0.0002883909],"category_scores_gemma":[0.00483587,0.000297171,0.000108676,0.001313095,0.0006597856,0.0002401929,0.0003437715,0.0004352421,0.000016856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000264405,"about_ca_system_score_gemma":0.0009608429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003619403,"about_ca_topic_score_gemma":0.00009001759,"domain_scores_codex":[0.9945378,0.0004794002,0.001041751,0.0008255352,0.002210637,0.0009048625],"domain_scores_gemma":[0.9951197,0.002211802,0.0002640747,0.0004884178,0.001588104,0.000327926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004537472,0.002135181,0.4772282,0.003963349,0.002893462,0.0001281813,0.01941979,0.00001382102,0.2666688,0.00103388,0.007536217,0.2144416],"study_design_scores_gemma":[0.008336673,0.0009813928,0.388686,0.00137694,0.0002727499,0.00006556165,0.004639449,0.003994507,0.5673363,0.001061715,0.02293001,0.0003187649],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891721,0.002178842,0.0000416024,0.0007875765,0.0000512587,0.002497363,0.0000301711,0.00002950804,0.005211572],"genre_scores_gemma":[0.9897303,0.004499019,0.001239179,0.00003519686,0.00004934751,0.0003977944,0.00009975264,0.00006030526,0.003889096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3006675,"threshold_uncertainty_score":0.999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06472119977396813,"score_gpt":0.3916399284627838,"score_spread":0.3269187286888157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}