{"id":"W2095276165","doi":"10.1038/gt.2013.70","title":"A novel gene therapy strategy using secreted multifunctional anti-HIV proteins to confer protection to gene-modified and unmodified target cells","year":2013,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Genetic enhancement; Biology; Gene delivery; Gene; Virology; Lentivirus; Human immunodeficiency virus (HIV); Computational biology; Genetics; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002415499,0.0004945172,0.0003811535,0.000201428,0.0002360217,0.0004490422,0.0004088969,0.0006635149,0.0004565121],"category_scores_gemma":[0.00009992669,0.0002215078,0.0003622679,0.0001501448,0.0003667699,0.0004264822,0.0003581663,0.0008296864,0.0002260504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003139165,"about_ca_system_score_gemma":0.0003283447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003097429,"about_ca_topic_score_gemma":0.0004454103,"domain_scores_codex":[0.999863,0.00001818747,0.000009985321,0.00003508537,0.00004382974,0.0000297819],"domain_scores_gemma":[0.9999413,0.000008974906,0.00001640039,0.000009911414,0.000009326181,0.00001397287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002804055,0.00002779807,0.00002823754,0.00002577745,0.000003725439,0.00005927517,0.00001854185,0.00008190324,0.9961558,0.0007471449,0.00007190357,0.002751953],"study_design_scores_gemma":[0.00001803869,0.0001843527,0.0002283595,0.000002457196,0.00001229795,0.0004410006,0.0000075781,0.0009477455,0.994889,0.0001418245,0.003120215,0.000007136905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8253362,0.00446981,0.1623987,0.0007646469,0.0004006377,0.0002674864,0.0002627449,0.0005650991,0.005534675],"genre_scores_gemma":[0.931201,0.001973072,0.05829151,0.0003386923,0.000041305,0.0001377133,0.0002119566,0.00004451805,0.007760233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006635149,"threshold_uncertainty_score":0.002277672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05634950845673442,"score_gpt":0.296787808672011,"score_spread":0.2404383002152766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}