{"id":"W2095312924","doi":"10.1006/bioo.2001.1206","title":"Effect of an E461G Mutation of β-Galactosidase (Escherichia coli, lac Z) on pL Rate Profiles and Solvent Deuterium Isotope Effects","year":2001,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences","keywords":"Chemistry; Kinetic isotope effect; Protonation; Nucleophile; Side chain; Catalysis; Leaving group; Deuterium; Stereochemistry; Solvent; Hydrolysis; Alkyl; Escherichia coli; Acid catalysis; Organic chemistry; Biochemistry; Ion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002141031,0.000215739,0.0002794317,0.00001635627,0.00003404687,0.0000106131,0.0001300784,0.000204101,0.00002943008],"category_scores_gemma":[0.0001372764,0.0001884053,0.00006748414,0.0001024013,0.00009486987,0.000006274229,0.00007447174,0.00008158262,0.000001914446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001002758,"about_ca_system_score_gemma":0.00005051047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001315753,"about_ca_topic_score_gemma":0.000001281881,"domain_scores_codex":[0.9990538,0.00008171993,0.0002294494,0.0003325907,0.0001084184,0.0001940158],"domain_scores_gemma":[0.9992734,0.00003235884,0.0001752713,0.0003430466,0.00006785077,0.0001080799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004813047,0.0001061104,0.0006592767,0.0004336664,0.00004645028,0.000008321414,0.00003194049,0.000002483595,0.9963498,0.000004556252,0.0001227244,0.00175341],"study_design_scores_gemma":[0.001256728,0.0008220381,0.005521904,0.0000502275,0.0000620037,0.00001973256,0.0000212285,0.0000394864,0.9906793,0.00000412478,0.001343602,0.0001795955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984698,0.0007808669,0.00009699931,0.00002239162,0.00006841947,0.0002668202,0.00002042408,0.00001358572,0.0002607417],"genre_scores_gemma":[0.998955,0.0002230064,0.0001074896,0.00005416289,0.0001718908,0.00002309481,0.000152221,0.00002943183,0.0002837279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005670425,"threshold_uncertainty_score":0.7682947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003736903432280623,"score_gpt":0.2250859798920239,"score_spread":0.2213490764597433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}