{"id":"W2095324015","doi":"10.1128/mcb.22.8.2673-2686.2002","title":"SKAP55 Coupled with CD45 Positively Regulates T-Cell Receptor-Mediated Gene Transcription","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; National Research Council Canada; Biotechnology Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Jurkat cells; FYN; T-cell receptor; Tyrosine-protein kinase CSK; Tyrosine kinase; Cell biology; Kinase; Phosphoprotein; Phosphorylation; Tyrosine phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Signal transduction; Molecular biology; T cell; SH3 domain; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323083,0.0004425909,0.0002616459,0.0002060212,0.000178222,0.0005180128,0.0001383352,0.000177656,0.001442975],"category_scores_gemma":[0.0001598453,0.000160585,0.0002418345,0.0001598031,0.0002115807,0.0001671356,0.0003415497,0.0004087464,0.0008548636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005192101,"about_ca_system_score_gemma":0.0001687831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004935419,"about_ca_topic_score_gemma":0.0007460301,"domain_scores_codex":[0.999747,0.00004081722,0.00001739348,0.00005408526,0.00005317667,0.00008757515],"domain_scores_gemma":[0.9998667,0.0000322725,0.00002722935,0.00001872569,0.00001184744,0.00004333133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005946945,0.00001002501,0.0001034712,0.00001567553,0.000001628449,0.00003296334,0.000006969668,0.00002871532,0.9990025,0.0000880955,0.00002974867,0.0006208069],"study_design_scores_gemma":[0.00001261424,0.0001048918,0.00299147,0.000004541277,0.0000110138,0.0001435341,0.00001806169,0.001038603,0.9934943,0.00004301717,0.002134708,0.00000308103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993507,0.00203581,0.002049725,0.00007440454,0.00004844972,0.00001378777,0.0002843299,0.00008687034,0.001899685],"genre_scores_gemma":[0.9965591,0.0005011991,0.0009167769,0.00003360675,0.000009727502,0.0000107034,0.0003209448,0.00001710488,0.001630773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442975,"threshold_uncertainty_score":0.004827201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005013371272529783,"score_gpt":0.1790020819406569,"score_spread":0.1739887106681271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}