{"id":"W2095324296","doi":"10.1136/jmg.2007.051268","title":"Germline E-cadherin mutations in familial lobular breast cancer","year":2007,"lang":"en","type":"letter","venue":"Journal of Medical Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Charles A. King Trust; Commonwealth of Massachusetts; Breast Cancer Research Foundation","keywords":"Cadherin; Germline; Germline mutation; Breast cancer; Genetics; Mutation; Medicine; Cancer; Biology; Cancer research; Oncology; Gene; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001806868,0.0003260899,0.0002055459,0.0008856332,0.0004009121,0.0002602961,0.0001947294,0.0004841542,0.001944976],"category_scores_gemma":[0.001096528,0.0001638562,0.0001174748,0.0005907915,0.0003921638,0.0001335245,0.0003195498,0.0002688486,0.000217037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002144307,"about_ca_system_score_gemma":0.0001797541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001619918,"about_ca_topic_score_gemma":0.001881459,"domain_scores_codex":[0.9998324,0.00002721611,0.00001651578,0.00004310588,0.00003702213,0.00004366257],"domain_scores_gemma":[0.9995325,0.0001912622,0.0001375839,0.00002148696,0.00003972374,0.00007747334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000217086,0.00004397446,0.9473851,0.00005033654,0.00003332797,0.03691723,0.0004189688,0.0001113702,0.008934171,0.00006310619,0.0002179233,0.005607259],"study_design_scores_gemma":[0.00001946871,0.0001732055,0.8823293,0.00002753589,0.00006386163,0.1132506,0.0003605592,0.0002377076,0.002557341,0.0001213076,0.0008499689,0.00000916408],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998858,0.000412133,0.0000881298,0.00002871749,0.000003033957,0.000005208992,0.00005230344,0.000006992413,0.000545555],"genre_scores_gemma":[0.9996779,0.0001062574,0.00007092502,0.00001875595,0.000004946039,0.000001910925,0.00003615283,0.000001355289,0.00008169829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001944976,"threshold_uncertainty_score":0.006506622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01648949947407916,"score_gpt":0.3192863961755218,"score_spread":0.3027968967014427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}