{"id":"W2095342509","doi":"10.1016/j.ymthe.2006.04.013","title":"The Mouse Dystrophin Muscle Promoter/Enhancer Drives Expression of Mini-dystrophin in Transgenic mdx Mice and Rescues the Dystrophy in These Mice","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Dystrophin; Utrophin; Enhancer; Duchenne muscular dystrophy; Biology; Transgene; Minigene; ITGA7; Muscular dystrophy; Skeletal muscle; mdx mouse; Sarcolemma; Molecular biology; Genetically modified mouse; Cell biology; Gene expression; Gene; Myocyte; Genetics; Exon; Endocrinology; Alternative splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003356742,0.000619989,0.0004614725,0.0007625056,0.0002596143,0.000360044,0.0005483208,0.0007991559,0.002375297],"category_scores_gemma":[0.0002130305,0.0005393706,0.0004048645,0.0002122174,0.000468521,0.0003622584,0.000424007,0.001626932,0.001525168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004053595,"about_ca_system_score_gemma":0.0003145747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008752713,"about_ca_topic_score_gemma":0.002635406,"domain_scores_codex":[0.9997821,0.00001871275,0.00003928615,0.0000528788,0.00006970675,0.00003726191],"domain_scores_gemma":[0.9996496,0.0000577913,0.0001278447,0.00004551978,0.00002992386,0.00008923192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003171134,0.00001302432,0.0001022654,0.0000225268,0.000003354492,0.00006849813,0.00001359973,0.00003882777,0.9987811,0.0003017953,0.00006628887,0.0005569611],"study_design_scores_gemma":[0.00003166231,0.00005128852,0.003245698,0.00001622309,0.00002163106,0.0007757108,0.00002875544,0.0009296527,0.9897821,0.0001569905,0.004952774,0.000007707256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9506606,0.001443037,0.03686995,0.0006982182,0.0002901614,0.0001441422,0.003608192,0.001200821,0.005085062],"genre_scores_gemma":[0.9367476,0.001564102,0.02723284,0.0002982598,0.00006644497,0.0002402502,0.004454371,0.0006780044,0.02871813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002375297,"threshold_uncertainty_score":0.007946193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004710959193148711,"score_gpt":0.2226144309578757,"score_spread":0.217903471764727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}