{"id":"W2095342509","doi":"10.1016/j.ymthe.2006.04.013","title":"The Mouse Dystrophin Muscle Promoter/Enhancer Drives Expression of Mini-dystrophin in Transgenic mdx Mice and Rescues the Dystrophy in These Mice","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Dystrophin; Utrophin; Enhancer; Duchenne muscular dystrophy; Biology; Transgene; Minigene; ITGA7; Muscular dystrophy; Skeletal muscle; mdx mouse; Sarcolemma; Molecular biology; Genetically modified mouse; Cell biology; Gene expression; Gene; Myocyte; Genetics; Exon; Endocrinology; Alternative splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002490678,0.0002272825,0.0002076612,0.00005350715,0.00009563369,0.00002342374,0.0003730772,0.0001677058,0.000005854243],"category_scores_gemma":[0.00002034684,0.0001422796,0.0001096474,0.0001385949,0.0003350071,0.000008713389,0.0000593827,0.0001782028,0.000001031824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009721597,"about_ca_system_score_gemma":0.0000368748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002672902,"about_ca_topic_score_gemma":0.0003191179,"domain_scores_codex":[0.9984415,0.0003612002,0.0003399654,0.000402169,0.0001347189,0.0003204897],"domain_scores_gemma":[0.9993348,0.00003939269,0.0001130769,0.0004453567,0.00003610006,0.00003125739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006097773,0.0001489434,0.0003530749,0.00001229385,0.00002104584,0.00000484315,0.000388006,0.0002528271,0.9962333,0.00008155167,0.00004597199,0.001848377],"study_design_scores_gemma":[0.001548778,0.000326119,0.02120883,0.00002629573,0.000006233609,0.000002327459,0.0002371546,0.00004291266,0.973744,0.0008636454,0.001807992,0.0001857467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904945,0.008190383,0.0002133381,0.0004799054,0.00003567321,0.0004650888,0.00001011393,0.000007631369,0.000103374],"genre_scores_gemma":[0.9976037,0.001798165,0.0001857071,0.0001206652,0.00004558843,0.00009133633,0.00002816794,0.00002937537,0.00009731159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02248932,"threshold_uncertainty_score":0.5801995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004710959193148711,"score_gpt":0.2226144309578757,"score_spread":0.217903471764727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}