{"id":"W2095368311","doi":"10.1038/ncomms3037","title":"Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2","year":2013,"lang":"en","type":"article","venue":"Nature Communications","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Division of Chemical, Bioengineering, Environmental, and Transport Systems; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Princess Margaret Hospital Foundation; National Cancer Institute; National Science Foundation; National Institutes of Health; Harvard University","keywords":"GRB2; SH2 domain; Modular design; Sequence (biology); Signal transducing adaptor protein; Phosphotyrosine-binding domain; Binding site; Stereochemistry; Protein structure; Protein tyrosine phosphatase; Tyrosine; Computational biology; Chemistry; Biology; Biochemistry; Signal transduction; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003725466,0.0003122283,0.0003555071,0.0001275137,0.000409257,0.0007121334,0.0005333705,0.0004352752,0.004368125],"category_scores_gemma":[0.0004886152,0.0004112475,0.0001790092,0.00009940455,0.0004684654,0.000665415,0.0007094963,0.001009427,0.0008642392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004676056,"about_ca_system_score_gemma":0.0002325059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004447789,"about_ca_topic_score_gemma":0.001486364,"domain_scores_codex":[0.9997833,0.00002369499,0.00001161462,0.0000550465,0.00006209269,0.00006433182],"domain_scores_gemma":[0.9996967,0.0001007783,0.00004252468,0.00002931351,0.00002475768,0.0001058894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002453496,0.00003347236,0.0003538656,0.00002255756,0.000009056789,0.00003707112,0.000017059,0.0003912503,0.9964737,0.0005354134,0.0001145428,0.001766712],"study_design_scores_gemma":[0.00007433816,0.0002028392,0.005674333,0.000007574499,0.00002218791,0.0003073213,0.00009853561,0.01819693,0.9729158,0.00088814,0.001578043,0.00003398218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953917,0.0001811306,0.002620368,0.0001473279,0.00002514235,0.000007815857,0.00005393111,0.00009000987,0.001482588],"genre_scores_gemma":[0.9985246,0.00007693771,0.0005139529,0.00007094779,0.000006577873,0.000008012064,0.00004552092,0.00003035758,0.0007231238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004368125,"threshold_uncertainty_score":0.01461285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579504773477675,"score_gpt":0.295721400783082,"score_spread":0.2799263530483052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}