{"id":"W2095375351","doi":"10.1203/00006450-200206000-00009","title":"A Randomized Crossover Trial of Combination Pharmacologic Therapy in Children with Familial Hyperlipidemia","year":2002,"lang":"en","type":"article","venue":"Pediatric Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Hospital for Sick Children; St. Joseph’s Healthcare Hamilton; University of Toronto; SickKids Foundation; St. Joseph's Hospital","funders":"","keywords":"Medicine; Regimen; Pravastatin; Adverse effect; Crossover study; Bile acid; Combination therapy; Internal medicine; Pill; Randomized controlled trial; Hyperlipidemia; Familial hypercholesterolemia; Gastroenterology; Pharmacology; Cholesterol; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005803188,0.0001172861,0.000720899,0.0004490268,0.00007440455,0.00001543728,0.0001279891,0.0001254214,0.0002414491],"category_scores_gemma":[0.0006086028,0.00007498284,0.0002194555,0.001052535,0.0001738711,0.0000691197,0.00003417832,0.0005832111,0.00002306998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001019858,"about_ca_system_score_gemma":0.0001943838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007590386,"about_ca_topic_score_gemma":0.000003854285,"domain_scores_codex":[0.9964665,0.00102003,0.0004294605,0.0002873603,0.001384675,0.0004120049],"domain_scores_gemma":[0.998793,0.0003834038,0.00008771686,0.0003181385,0.0002957102,0.0001220196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8671778,0.00189141,0.1048026,0.00009737022,0.0002626267,0.0000203503,0.0003285618,0.000009780098,0.0001010182,0.0001044214,0.001394432,0.02380961],"study_design_scores_gemma":[0.9538866,0.001812378,0.04334782,0.000007905587,0.00007132735,0.00001506058,0.00001727467,0.0003832097,0.0001625079,0.00008480727,0.0001278895,0.00008316135],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896599,0.002926998,0.00001590407,0.0003790662,0.00007900281,0.005183213,0.000002877153,0.00001984384,0.001733196],"genre_scores_gemma":[0.9839396,0.01410395,0.00008531722,0.00006142245,0.001077581,0.000385302,0.000007944776,0.00001790563,0.000321013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08670881,"threshold_uncertainty_score":0.3057711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07697314941281047,"score_gpt":0.3789741773776821,"score_spread":0.3020010279648716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}