{"id":"W2095390308","doi":"10.1006/abio.2000.4542","title":"Measurement of Phenyllactate, Phenylacetate, and Phenylpyruvate by Negative Ion Chemical Ionization–Gas Chromatography/Mass Spectrometry in Brain of Mouse Genetic Models of Phenylketonuria and Non-Phenylketonuria Hyperphenylalaninemia","year":2000,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"","keywords":"Hyperphenylalaninemia; Phenylacetate; Chemistry; Phenylalanine; Chemical ionization; Mass spectrometry; Phenylpyruvic acid; Gas chromatography–mass spectrometry; Phenylketonurias; Isotope dilution; Chromatography; Biochemistry; Endocrinology; Internal medicine; Amino acid; Ionization; Organic chemistry; Medicine; Ion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003719561,0.0004358228,0.0007824812,0.000130948,0.00003632532,0.00001656531,0.0002862457,0.0003487043,0.0001202761],"category_scores_gemma":[0.0001817458,0.0004387199,0.0001922212,0.0005478185,0.0006991246,0.00001775654,0.0001030182,0.0001690159,8.506317e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001554194,"about_ca_system_score_gemma":0.0001394162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009605607,"about_ca_topic_score_gemma":0.00000662612,"domain_scores_codex":[0.9972036,0.00008987447,0.000973455,0.0007739648,0.0005181233,0.0004409955],"domain_scores_gemma":[0.9986237,0.00004717954,0.0002908207,0.0005470052,0.0002560866,0.0002352068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003330004,0.0003043505,0.006163173,0.0003727933,0.0002386967,0.000001380939,0.0001004452,0.000145066,0.990659,0.00003160825,0.0006043051,0.001046189],"study_design_scores_gemma":[0.002448363,0.0001867,0.002306028,0.0001135403,0.0001401676,0.000006485836,0.0001869873,0.003265152,0.9902393,0.0006335255,0.00005481208,0.0004188923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992444,0.004562156,0.0009568959,0.00008126572,0.00002144321,0.0003011269,0.0001280277,0.00001181898,0.001493249],"genre_scores_gemma":[0.9939921,0.001763659,0.003773978,0.00005923982,0.00005010365,0.00001682451,0.0001070898,0.00004417526,0.0001928515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003857145,"threshold_uncertainty_score":0.9998065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004567539726946477,"score_gpt":0.2065558513683541,"score_spread":0.2019883116414076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}