{"id":"W2095400080","doi":"10.1534/genetics.106.070300","title":"The Biologically Relevant Targets and Binding Affinity Requirements for the Function of the Yeast Actin-Binding Protein 1 Src-Homology 3 Domain Vary With Genetic Context","year":2007,"lang":"en","type":"article","venue":"Genetics","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Biology; SH3 domain; Mutant; Binding domain; Context (archaeology); Function (biology); Plasma protein binding; Cell biology; Phenotype; Protein–protein interaction; Yeast; Actin cytoskeleton; Actin; Genetics; Binding site; Proto-oncogene tyrosine-protein kinase Src; Cytoskeleton; Cell; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257095,0.0004066123,0.0002432653,0.0001956762,0.0002096513,0.0003903656,0.0003185655,0.0003121688,0.001159974],"category_scores_gemma":[0.0001486259,0.0002424762,0.00020733,0.0001245671,0.0003057058,0.0002146918,0.0003355692,0.0005787817,0.0003804885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003809333,"about_ca_system_score_gemma":0.0002132953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001147065,"about_ca_topic_score_gemma":0.001773963,"domain_scores_codex":[0.9997694,0.00003817505,0.00002104278,0.00004449839,0.00008982108,0.00003694306],"domain_scores_gemma":[0.9998251,0.00004794308,0.00005030994,0.00002131212,0.00001467915,0.00004069726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000246209,0.000005839555,0.0001352713,0.000007344398,0.000001655388,0.00002138226,0.000003292553,0.00004865338,0.9995183,0.00002454529,0.000002805298,0.0002063481],"study_design_scores_gemma":[0.000007494458,0.00008675027,0.01073887,0.000002551291,0.00001336993,0.0003739181,0.00003577104,0.001076203,0.9869586,0.00005839855,0.0006430023,0.000004953964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975933,0.0004030435,0.001375709,0.00003236957,0.000003826431,0.000006226187,0.00009238184,0.00002165482,0.0004714303],"genre_scores_gemma":[0.9981048,0.0001655271,0.001101709,0.00001641432,0.000001691722,0.000009099792,0.0002013636,0.0000154186,0.0003839927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001159974,"threshold_uncertainty_score":0.003880501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02355405124531258,"score_gpt":0.2689548941829332,"score_spread":0.2454008429376206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}