{"id":"W2095400080","doi":"10.1534/genetics.106.070300","title":"The Biologically Relevant Targets and Binding Affinity Requirements for the Function of the Yeast Actin-Binding Protein 1 Src-Homology 3 Domain Vary With Genetic Context","year":2007,"lang":"en","type":"article","venue":"Genetics","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Biology; SH3 domain; Mutant; Binding domain; Context (archaeology); Function (biology); Plasma protein binding; Cell biology; Phenotype; Protein–protein interaction; Yeast; Actin cytoskeleton; Actin; Genetics; Binding site; Proto-oncogene tyrosine-protein kinase Src; Cytoskeleton; Cell; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009328982,0.0001890462,0.0001443453,0.00003069099,0.000586908,0.00003774227,0.0004255758,0.0001735369,0.000005828343],"category_scores_gemma":[0.0001443987,0.00009128707,0.00008047838,0.0001429189,0.0005223138,0.000002305453,0.0003195986,0.0001805693,0.000002459214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001929611,"about_ca_system_score_gemma":0.0001032755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007397914,"about_ca_topic_score_gemma":0.0002295312,"domain_scores_codex":[0.9984588,0.0001473473,0.0003115646,0.0003487367,0.0002481411,0.0004854228],"domain_scores_gemma":[0.9989244,0.000148367,0.0001936191,0.0004762379,0.0001801216,0.00007727513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006828788,0.00003892335,0.004920695,0.00002473125,0.0001133571,0.000001305305,0.00005057356,0.00003468701,0.978102,0.0001105147,0.0001771762,0.01574319],"study_design_scores_gemma":[0.001168905,0.001977937,0.0295885,0.00003781466,0.00006291321,0.00003713322,0.000858914,0.00006868732,0.9347194,0.0005325423,0.0306984,0.000248793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903325,0.00223178,0.005558116,0.0004094648,0.000202091,0.001097704,0.00003996152,0.000005912978,0.0001224982],"genre_scores_gemma":[0.9968089,0.0003977027,0.001952615,0.00008042617,0.000173477,0.00007499062,0.00001596552,0.00002592783,0.0004699707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04338251,"threshold_uncertainty_score":0.4514081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02355405124531258,"score_gpt":0.2689548941829332,"score_spread":0.2454008429376206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}