{"id":"W2095405582","doi":"10.1038/nri1787","title":"cFLIP regulation of lymphocyte activation and development","year":2006,"lang":"en","type":"review","venue":"Nature reviews. Immunology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":277,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"National Cancer Institute; National Institutes of Health","keywords":"FADD; Death domain; Cell biology; Caspase 8; Biology; Signal transduction; Apoptosis; Programmed cell death; T cell; Receptor; Cancer research; Caspase; Immune system; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005013475,0.001160192,0.001106564,0.001244682,0.0003382576,0.001182148,0.001093237,0.001606933,0.003344033],"category_scores_gemma":[0.0003362026,0.0002740209,0.0002714518,0.001086128,0.00073774,0.001121787,0.000764696,0.001842096,0.002821581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001085442,"about_ca_system_score_gemma":0.0007860973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008339714,"about_ca_topic_score_gemma":0.001371862,"domain_scores_codex":[0.9998259,0.00001396056,0.00001363599,0.00003335717,0.00007824913,0.00003488452],"domain_scores_gemma":[0.9998333,0.00005079322,0.0000223213,0.000008550798,0.00004932673,0.000035699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000198216,0.00004662005,0.0001380025,0.002911217,0.0000291361,0.0003292006,0.00002754552,0.0003232846,0.02078925,0.005495341,0.05007675,0.9196354],"study_design_scores_gemma":[0.0000470972,0.0000845539,0.001222708,0.0008623921,0.00004429929,0.001216445,0.0000352736,0.0001514809,0.005441731,0.002768434,0.9881055,0.00002007682],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004534303,0.9930495,0.0007832921,0.000703782,0.001407325,0.00001084919,0.00004029914,0.00005490303,0.003496552],"genre_scores_gemma":[0.00448915,0.9877913,0.0006179403,0.0005872686,0.001069209,0.00002764492,0.0001193516,0.000006805801,0.005291351],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003344033,"threshold_uncertainty_score":0.0111869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01779234898070187,"score_gpt":0.2937225928700856,"score_spread":0.2759302438893837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}