{"id":"W2095408752","doi":"10.1007/s00262-012-1333-2","title":"CD40 pathway activation reveals dual function for macrophages in human endometrial cancer cell survival and invasion","year":2012,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"CD40; Cancer research; Tumor necrosis factor alpha; Endometrial cancer; Biology; Apoptosis; Cancer cell; Macrophage; Cancer; Tumor progression; PI3K/AKT/mTOR pathway; Signal transduction; Immunology; Medicine; Cell biology; Internal medicine; In vitro; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009806225,0.0005034439,0.0007832289,0.0003515546,0.000483879,0.00003367618,0.0003113478,0.0008176432,0.00204398],"category_scores_gemma":[0.00006758158,0.0004941836,0.00016925,0.0003667402,0.0004622434,0.0005930197,0.0001197859,0.000635505,0.00003343043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006992023,"about_ca_system_score_gemma":0.0001693084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002034169,"about_ca_topic_score_gemma":0.0001744411,"domain_scores_codex":[0.9968783,0.0005437834,0.0007830015,0.0006123547,0.0000821735,0.001100358],"domain_scores_gemma":[0.9982247,0.0005612124,0.0004858816,0.0005415633,0.0001551196,0.00003154511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003098164,0.0002626238,0.01022122,0.00005440978,0.0004559594,5.800192e-7,0.00111101,0.000008310282,0.9389313,0.0006616497,0.000788773,0.04440599],"study_design_scores_gemma":[0.0152961,0.000634096,0.06791699,0.000121083,0.00006698087,0.00001186112,0.0006905994,8.722716e-7,0.8323557,0.0002937181,0.08198518,0.0006268111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7844467,0.2054903,0.0002853376,0.0001862661,0.007920157,0.001129236,0.00009456954,0.00009321848,0.0003542117],"genre_scores_gemma":[0.977127,0.01726156,0.00006871529,0.0003641504,0.0003836416,0.001507877,0.0001925516,0.0001094346,0.002985046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1926803,"threshold_uncertainty_score":0.999751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03009276994337028,"score_gpt":0.2928797830980133,"score_spread":0.262787013154643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}