{"id":"W2095417278","doi":"10.1038/mp.2015.4","title":"Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics","year":2015,"lang":"en","type":"review","venue":"Molecular Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":318,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Lithium (medication); CREB; Pharmacogenetics; Bipolar disorder; Neuroscience; Mechanism (biology); Pharmacology; Population; Treatment of bipolar disorder; Psychology; Bioinformatics; Drug response; Drug; Medicine; Computational biology; Biology; Psychiatry; Genetics; Gene; Genotype; Mania","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006652422,0.0008916704,0.002294822,0.002130416,0.0002260978,0.001032554,0.001063082,0.0009959328,0.002867337],"category_scores_gemma":[0.000980542,0.0003000322,0.0007491183,0.002293464,0.0004368652,0.0009743682,0.0006871684,0.00189214,0.0008701078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005318059,"about_ca_system_score_gemma":0.00107202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001668201,"about_ca_topic_score_gemma":0.005335431,"domain_scores_codex":[0.9997814,0.00004509755,0.00005040937,0.00003331569,0.00007538128,0.00001441727],"domain_scores_gemma":[0.999505,0.0002798859,0.00009226356,0.00001239633,0.00007970921,0.00003069186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002121795,0.00008564468,0.0002712705,0.02319696,0.0003059105,0.0001641544,0.00003769561,0.0003752937,0.0008434697,0.00160519,0.01824342,0.9546588],"study_design_scores_gemma":[0.0002544494,0.0003443551,0.002479805,0.01397206,0.001449018,0.002321251,0.0001000626,0.0004054748,0.0006607577,0.004253477,0.9736883,0.00007112895],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007689278,0.9993406,0.00005265887,0.0001392264,0.00006900194,0.000002574035,0.00001325787,0.000003663919,0.0003020946],"genre_scores_gemma":[0.0005509116,0.9988292,0.000144009,0.0001749868,0.0001246962,0.000003323669,0.00001950007,7.979033e-7,0.0001526409],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002867337,"threshold_uncertainty_score":0.009592235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02655512950649468,"score_gpt":0.3610744063263508,"score_spread":0.3345192768198561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}