{"id":"W2095476038","doi":"10.1371/journal.pone.0045842","title":"Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Vaccination; Virology; Innate immune system; Coronavirus; Interferon; Immunology; Coronavirus disease 2019 (COVID-19); Biology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Medicine; Immune system; Infectious disease (medical specialty); Outbreak; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005524607,0.00106443,0.0007294119,0.0008093073,0.0003864944,0.0005525929,0.000586568,0.001189197,0.00104615],"category_scores_gemma":[0.0003425282,0.0003288318,0.0006263091,0.0001316585,0.0009902291,0.0007840075,0.0003111864,0.001295552,0.0004270377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001017328,"about_ca_system_score_gemma":0.0003565962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009600309,"about_ca_topic_score_gemma":0.001418327,"domain_scores_codex":[0.999554,0.00006310061,0.00003582332,0.0001816268,0.00006804589,0.00009741502],"domain_scores_gemma":[0.9996296,0.00005607493,0.0001233283,0.00007665608,0.00002998193,0.00008422365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001138819,0.000581935,0.001385906,0.00005297444,0.00002521774,0.0004647314,0.0001511752,0.0003635509,0.9938055,0.000255639,0.0001522418,0.001622268],"study_design_scores_gemma":[0.0002579946,0.01303928,0.02133422,0.00005478896,0.000126272,0.003618858,0.000443482,0.005653721,0.9507908,0.0007172596,0.003909471,0.00005392483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963619,0.0004390014,0.001773643,0.0002018846,0.00005455469,0.0001282432,0.0003272304,0.0001001587,0.0006133775],"genre_scores_gemma":[0.9936691,0.0003134679,0.001772542,0.0001230279,0.00002310004,0.0002912484,0.0007200359,0.00002787482,0.003059699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189197,"threshold_uncertainty_score":0.00738132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2017729222979655,"score_gpt":0.391704839754825,"score_spread":0.1899319174568595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}