{"id":"W2095518647","doi":"10.1007/s11060-011-0594-5","title":"Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: a systematic review and meta-analysis","year":2011,"lang":"en","type":"review","venue":"Journal of Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Medicine; Oncology; Internal medicine; Meta-analysis; Chemoradiotherapy; Methyltransferase; Radiation therapy; Adjuvant; Methylation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004485788,0.001662698,0.008896055,0.00212589,0.0004009234,0.001403843,0.00157927,0.001481921,0.001918503],"category_scores_gemma":[0.01091162,0.001066204,0.01984338,0.003821939,0.0004620941,0.001073859,0.001067754,0.001243685,0.0001960364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008590348,"about_ca_system_score_gemma":0.001249973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004172354,"about_ca_topic_score_gemma":0.01237464,"domain_scores_codex":[0.9975163,0.0009504129,0.0006588361,0.0005130644,0.0002516687,0.0001098812],"domain_scores_gemma":[0.993616,0.00444928,0.001131969,0.0002735362,0.0003971496,0.000132078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004621984,0.00005477436,0.03599903,0.1054555,0.8304266,0.0002934476,0.0001467815,0.0007283585,0.0006413397,0.00009266435,0.0006886962,0.02085084],"study_design_scores_gemma":[0.0004321902,0.0002441679,0.01533147,0.002930644,0.9793266,0.0001503016,0.00005349445,0.0001714825,0.0001419623,0.0001238146,0.00106656,0.00002726841],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03094159,0.967284,0.0005694476,0.000178463,0.0001557822,0.00008593393,0.0005341783,0.00001882501,0.0002318491],"genre_scores_gemma":[0.5810291,0.4147156,0.001790814,0.0006355328,0.0002376081,0.0001847944,0.0009686578,0.00002463246,0.0004132148],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008896055,"threshold_uncertainty_score":0.02372336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05344352304487181,"score_gpt":0.3240987726050287,"score_spread":0.2706552495601569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}