{"id":"W2095532898","doi":"10.1002/art.30549","title":"Imatinib in active diffuse cutaneous systemic sclerosis: Results of a six‐month, randomized, double‐blind, placebo‐controlled, proof‐of‐concept pilot study at a single center","year":2011,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; McMaster University; St Joseph's Health Care; Western University","funders":"","keywords":"Medicine; Placebo; Tolerability; Nausea; Internal medicine; Adverse effect; Imatinib; Erythrocyte sedimentation rate; Surgery; Single Center; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009571288,0.0005064642,0.003096328,0.0004263198,0.0001035255,0.00002519353,0.0002651658,0.0001898144,0.0002021975],"category_scores_gemma":[0.0006774267,0.0003895201,0.0004444612,0.0003679178,0.0003957653,0.0002098698,0.0001508453,0.0002923298,0.00002416817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000192437,"about_ca_system_score_gemma":0.0001298645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0022936,"about_ca_topic_score_gemma":0.0008918164,"domain_scores_codex":[0.9941907,0.0007765686,0.003012115,0.0007100893,0.0007564208,0.0005540967],"domain_scores_gemma":[0.996385,0.0007303323,0.001497112,0.0008098446,0.0003046583,0.0002730771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9287236,0.01353237,0.001901179,0.0003099068,0.001364131,0.0001690654,0.03018344,0.00002722735,0.005921553,0.00007126798,0.0002177869,0.01757841],"study_design_scores_gemma":[0.9379387,0.004658274,0.0006466472,0.041978,0.000470904,0.0006886842,0.007036014,0.0002199541,0.005959332,0.00003660027,0.000001270808,0.0003656421],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615884,0.02299504,0.00002312667,0.00003864407,0.0004035909,0.01100655,0.000185183,0.00008677252,0.003672714],"genre_scores_gemma":[0.9947692,0.003366498,0.0001406416,0.0000255459,0.00003881342,0.001330382,0.00005619499,0.0000747392,0.0001979812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04166809,"threshold_uncertainty_score":0.9998557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04562273304418022,"score_gpt":0.2512634169671852,"score_spread":0.205640683923005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}