{"id":"W2095557517","doi":"10.1016/j.gendis.2014.09.002","title":"Highly efficient retinal gene delivery with helper-dependent adenoviral vectors","year":2014,"lang":"en","type":"article","venue":"Genes & Diseases","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; U.S. Public Health Service; University of British Columbia; Foundation Fighting Blindness; Zoetis","keywords":"ABCA4; RPE65; Genetic enhancement; Transgene; Stargardt disease; Gene delivery; Biology; Retinal; Retinal pigment epithelium; Cis-trans-Isomerases; Retina; Retinal degeneration; Viral vector; Gene; Vectors in gene therapy; Reporter gene; Retinitis pigmentosa; Gene expression; Genetics; Recombinant DNA; Neuroscience; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006859469,0.0002195922,0.0001457219,0.00004718225,0.0001308782,0.00004164219,0.0002035374,0.00007033225,0.0000377123],"category_scores_gemma":[0.00002846394,0.0001788412,0.00008961868,0.00008100997,0.00009728187,0.000003260359,0.0001091301,0.00004088395,0.00004502805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001478485,"about_ca_system_score_gemma":0.000108286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002272076,"about_ca_topic_score_gemma":0.00002142518,"domain_scores_codex":[0.9987407,0.00006023411,0.0001633665,0.0004382722,0.0002697077,0.0003277033],"domain_scores_gemma":[0.999373,0.000010201,0.00006519494,0.0002957287,0.00008191789,0.0001739217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002519195,0.0006149355,0.3247375,0.0001262124,0.0002782741,0.00005272685,0.0001321618,0.005292394,0.6383983,0.0001995136,0.004372139,0.02327666],"study_design_scores_gemma":[0.003650178,0.002196943,0.5084109,0.00008056818,0.0003524554,0.00006879622,0.0004796633,0.0003042982,0.3928331,0.00008226667,0.08972073,0.001820092],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941674,0.00401458,0.0006653707,0.000094066,0.0001503248,0.0001508399,0.00002576093,0.0000340296,0.0006975858],"genre_scores_gemma":[0.9980292,0.0002433567,0.0003623052,0.0002585856,0.0002561989,0.0000319535,0.0002733549,0.0000297952,0.0005153072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2455652,"threshold_uncertainty_score":0.7292931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003891345951400376,"score_gpt":0.1930911666833436,"score_spread":0.1891998207319433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}