{"id":"W2095557517","doi":"10.1016/j.gendis.2014.09.002","title":"Highly efficient retinal gene delivery with helper-dependent adenoviral vectors","year":2014,"lang":"en","type":"article","venue":"Genes & Diseases","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; U.S. Public Health Service; University of British Columbia; Foundation Fighting Blindness; Zoetis","keywords":"ABCA4; RPE65; Genetic enhancement; Transgene; Stargardt disease; Gene delivery; Biology; Retinal; Retinal pigment epithelium; Cis-trans-Isomerases; Retina; Retinal degeneration; Viral vector; Gene; Vectors in gene therapy; Reporter gene; Retinitis pigmentosa; Gene expression; Genetics; Recombinant DNA; Neuroscience; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005306908,0.000447755,0.0003168022,0.0004419089,0.0001680551,0.0005664642,0.0003438363,0.0003810032,0.001230325],"category_scores_gemma":[0.0002741654,0.0002415628,0.0002513991,0.000234432,0.0003107023,0.0003735749,0.0003050024,0.0008187531,0.0007132486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000400369,"about_ca_system_score_gemma":0.0004346891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001103295,"about_ca_topic_score_gemma":0.001307196,"domain_scores_codex":[0.9996096,0.00005075775,0.00004945958,0.00008641037,0.0001422381,0.00006144406],"domain_scores_gemma":[0.999837,0.00004230016,0.00004314433,0.00002622785,0.00002322808,0.00002800956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003665463,0.00002566935,0.00008986052,0.00004866251,0.000005470529,0.00005201661,0.00003145245,0.00009951834,0.9960781,0.0004686645,0.00008951574,0.002974367],"study_design_scores_gemma":[0.00002939159,0.0002372395,0.0006526806,0.00001036549,0.00001503908,0.0002529041,0.00002671881,0.001469312,0.9882432,0.0001333952,0.008918406,0.00001140438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7977969,0.006916627,0.1843171,0.0003535605,0.0002497466,0.0008262667,0.001316899,0.001255545,0.006967292],"genre_scores_gemma":[0.8823929,0.004076512,0.1010299,0.0001131518,0.00004569266,0.0002244377,0.001300015,0.0001534765,0.01066407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001230325,"threshold_uncertainty_score":0.00411588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003891345951400376,"score_gpt":0.1930911666833436,"score_spread":0.1891998207319433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}