{"id":"W2095599995","doi":"10.1200/jco.2014.60.0734","title":"Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":421,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; Children's Hospital of Pittsburgh; University College London; National Cancer Institute; University of Nottingham; Hospital for Sick Children; Deutsche Krebshilfe; Universitair Medisch Centrum Groningen; Connecticut Children's Medical Center; Medical Research Council; Children’s Oncology Group; Leids Universitair Medisch Centrum; Dalhousie University; Cliniques Universitaires Saint-Luc; Children's Hospitals and Clinics of Minnesota; Bundesministerium für Bildung und Forschung; Radboud Universiteit; Children's Hospital Colorado; Cleveland Clinic; Universiteit Leiden; Universität Wien; Deutsche Forschungsgemeinschaft; European Science Foundation; University of Leeds; Cancer Research UK; Cedars-Sinai Medical Center; Universitätsspital Basel; Memorial Sloan-Kettering Cancer Center; Ochsner Health; Saint Luke's Health System; European Commission; Nationwide Children's Hospital; Helsingin Yliopisto; Children's Healthcare of Atlanta; Vlaamse regering; National Institute for Health and Care Research; BC Children's Hospital; Arcadia Fund; Medizinische Universität Wien; Carilion Clinic; Norges Forskningsråd; Pennsylvania State University; Sundhed og Sygdom, Det Frie Forskningsråd; Cleveland Clinic Foundation; Cincinnati Children's Hospital Medical Center; Children's National Hospital; University of Pennsylvania; Children's Hospital of Philadelphia","keywords":"Medicine; Chemotherapy; Surgery; Methotrexate; Toxicity; Cisplatin; Osteosarcoma; Doxorubicin; Internal medicine; Gastroenterology; Urology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001902193,0.0007834567,0.001836597,0.0003772139,0.0002569604,0.0007603589,0.0005324581,0.0008922032,0.00246211],"category_scores_gemma":[0.001469987,0.0004223064,0.001595685,0.0003961758,0.0006151297,0.0005560762,0.0003139045,0.001442579,0.000332091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005958385,"about_ca_system_score_gemma":0.0008810292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006047852,"about_ca_topic_score_gemma":0.001468743,"domain_scores_codex":[0.9993389,0.0004022249,0.00006459542,0.00009643139,0.00003951589,0.00005829558],"domain_scores_gemma":[0.99923,0.0001879225,0.0003075336,0.00004755705,0.00003568134,0.0001912426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9769773,0.003456481,0.001713378,0.0006500878,0.0009350808,0.0000231673,0.00003054414,0.000197345,0.001353228,0.00004569629,0.0003185891,0.01429912],"study_design_scores_gemma":[0.8964856,0.09630234,0.004938583,0.00007842361,0.0008566667,0.00005630279,0.00002160917,0.0003480438,0.000361822,0.00008706254,0.000454961,0.000008560243],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900249,0.007191272,0.0002224889,0.0004095387,0.0002249806,0.0009577012,0.0002573241,0.0000302024,0.0006816139],"genre_scores_gemma":[0.9937861,0.002462553,0.0005644077,0.0006309949,0.0002490332,0.001113945,0.0003438185,0.000005857432,0.0008433564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00246211,"threshold_uncertainty_score":0.01005989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06444841696875124,"score_gpt":0.3770202253801115,"score_spread":0.3125718084113603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}