{"id":"W2095606487","doi":"10.1086/522611","title":"RAD51 135G→C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies","year":2007,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":243,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Medical Research and Materiel Command; National Center for Research Resources; Cancer Council Queensland; Institut Curie; Canadian Institutes of Health Research; National Institutes of Health; Deutsche Krebshilfe; National Cancer Institute; Cancer Research UK; KWF Kankerbestrijding; Israel Cancer Association; Ministerstvo Školství, Mládeže a Tělovýchovy; National Breast Cancer Foundation; National Health and Medical Research Council; Cancer Care Ontario; Academy of Finland; Nebraska Department of Health and Human Services; Cure JM Foundation; Ministry of Health; Mayo Clinic; Tel Aviv University; Breast Cancer Research Foundation; Univerzita Karlova v Praze; Susan G. Komen; Helsingin ja Uudenmaan Sairaanhoitopiiri","keywords":"Heterozygote advantage; RAD51; Breast cancer; Genotype; SNP; Mutation; Hazard ratio; Oncology; Single-nucleotide polymorphism; Cancer research; Internal medicine; Biology; BRCA2 Protein; Medicine; Genetics; Confidence interval; DNA repair; Molecular biology; Cancer; Germline mutation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007927038,0.0001771894,0.0004857143,0.0002339434,0.0001633501,0.000019837,0.0004008538,0.00004810746,0.00001041962],"category_scores_gemma":[0.0001435955,0.0001351993,0.0002616554,0.000598309,0.0009610569,0.000006022899,0.00008564685,0.0001677272,3.118695e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001190724,"about_ca_system_score_gemma":0.0001692283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009349284,"about_ca_topic_score_gemma":0.001531402,"domain_scores_codex":[0.9982326,0.0002053639,0.0007978542,0.0002208637,0.0003331524,0.000210185],"domain_scores_gemma":[0.9966764,0.0001455808,0.001933816,0.00046527,0.0006850656,0.00009389078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005878495,0.0003076133,0.3010441,0.00003281027,0.0416819,0.00004755538,0.03035335,0.2688948,0.2865446,0.00002570783,0.004174178,0.06101487],"study_design_scores_gemma":[0.002082086,0.001401629,0.8865531,0.00004906033,0.004570105,0.00002302965,0.02072956,0.0005652076,0.08294823,0.000492058,0.0002306836,0.0003552539],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933289,0.004535263,0.001218697,0.0001862428,0.0001557145,0.00009411498,0.0004465045,0.00000381566,0.00003075386],"genre_scores_gemma":[0.9957837,0.002636935,0.001023732,0.0001141969,0.000331398,0.000003592427,0.00004475189,0.00002221618,0.00003949485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.585509,"threshold_uncertainty_score":0.5513265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01814885933315587,"score_gpt":0.3240468812084576,"score_spread":0.3058980218753017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}