{"id":"W2095606487","doi":"10.1086/522611","title":"RAD51 135G→C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies","year":2007,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":243,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Medical Research and Materiel Command; National Center for Research Resources; Cancer Council Queensland; Institut Curie; Canadian Institutes of Health Research; National Institutes of Health; Deutsche Krebshilfe; National Cancer Institute; Cancer Research UK; KWF Kankerbestrijding; Israel Cancer Association; Ministerstvo Školství, Mládeže a Tělovýchovy; National Breast Cancer Foundation; National Health and Medical Research Council; Cancer Care Ontario; Academy of Finland; Nebraska Department of Health and Human Services; Cure JM Foundation; Ministry of Health; Mayo Clinic; Tel Aviv University; Breast Cancer Research Foundation; Univerzita Karlova v Praze; Susan G. Komen; Helsingin ja Uudenmaan Sairaanhoitopiiri","keywords":"Heterozygote advantage; RAD51; Breast cancer; Genotype; SNP; Mutation; Hazard ratio; Oncology; Single-nucleotide polymorphism; Cancer research; Internal medicine; Biology; BRCA2 Protein; Medicine; Genetics; Confidence interval; DNA repair; Molecular biology; Cancer; Germline mutation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003428156,0.001655425,0.00212746,0.004230348,0.0009506562,0.001221436,0.0009533964,0.001112581,0.00327949],"category_scores_gemma":[0.004384921,0.000899239,0.003152118,0.004514712,0.0007012061,0.0005591811,0.001320427,0.0005694086,0.0004494684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003988042,"about_ca_system_score_gemma":0.0004294002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005503164,"about_ca_topic_score_gemma":0.006793139,"domain_scores_codex":[0.995846,0.002025858,0.0003490602,0.001034952,0.0004260496,0.000318091],"domain_scores_gemma":[0.9946474,0.002556244,0.001178806,0.0006640024,0.0005063186,0.0004471439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.007236502,0.0001072332,0.9561626,0.0001588619,0.01875369,0.001083073,0.0002645695,0.0002054518,0.010389,0.00004538959,0.0002128505,0.0053808],"study_design_scores_gemma":[0.0002472029,0.0006385099,0.9786463,0.00004015283,0.01638449,0.00156587,0.0001739548,0.0001789012,0.001386125,0.00005119645,0.0006613376,0.00002590331],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926796,0.005078124,0.0004061205,0.00006119121,0.00001784409,0.00002969901,0.001056668,0.000017844,0.0006530304],"genre_scores_gemma":[0.9981046,0.0006868751,0.0003039482,0.00003361781,0.00001779774,0.00001688083,0.0006026177,0.00001660673,0.0002170356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005503164,"threshold_uncertainty_score":0.01813006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01814885933315587,"score_gpt":0.3240468812084576,"score_spread":0.3058980218753017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}