{"id":"W2095642631","doi":"10.1093/emboj/19.18.4986","title":"Activation of the β globin locus by transcription factors and chromatin modifiers","year":2000,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Medical Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Biology; Chromatin; Transcription (linguistics); Locus control region; Genetics; Locus (genetics); Globin; Transcription factor; Molecular biology; Cell biology; Gene; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001403033,0.0003323729,0.0001441009,0.0001696113,0.0001986742,0.0004211144,0.0001962191,0.00018048,0.001547302],"category_scores_gemma":[0.0002385403,0.0002016594,0.0001751961,0.0001176668,0.0002924438,0.0002474609,0.0003430561,0.0004675626,0.0004727631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003392947,"about_ca_system_score_gemma":0.0001407244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008812741,"about_ca_topic_score_gemma":0.001210976,"domain_scores_codex":[0.9998839,0.00002084108,0.000004793106,0.00003113761,0.00002271512,0.00003659249],"domain_scores_gemma":[0.9998555,0.00004587027,0.00002265381,0.00002419703,0.0000153075,0.00003645728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001744427,0.000006132735,0.0005227578,0.00001114371,0.000003531544,0.00005610145,0.00002280607,0.00005411219,0.9963583,0.0007196542,0.00003783163,0.002033081],"study_design_scores_gemma":[0.00001835131,0.00007614062,0.01348453,0.000007432914,0.00001067003,0.0001975049,0.00006174617,0.0007309744,0.9817004,0.0007665701,0.002939899,0.000005868138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978025,0.005062782,0.009466933,0.0003854259,0.00007251239,0.00001342727,0.0001798544,0.0001413838,0.006652677],"genre_scores_gemma":[0.994082,0.000807925,0.0007142804,0.00006112726,0.0000152799,0.000006584214,0.0002096211,0.0000276243,0.004075617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001547302,"threshold_uncertainty_score":0.005176246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0080381642024138,"score_gpt":0.2197923028366617,"score_spread":0.2117541386342479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}